Human papillomavirus, radiation dose and survival of patients with anal cancer.

Human papillomavirus, radiation dose and survival of patients with anal cancer. Acta Oncol. 2019 Jul 08;:1-7 Authors: Kabarriti R, Brodin NP, Ohri N, Narang R, Huang R, Chuy JW, Rajdev LN, Kalnicki S, Guha C, Garg MK Abstract Purpose: To determine if anal cancer patients with HPV positive disease have different overall survival (OS) compared to those with HPV negative disease, and to elucidate differences in the association between radiation dose and OS. Patients and methods: We utilized the National Cancer Database (NCDB) registry to identify a cohort of non-metastatic anal cancer patients treated with curative intent between 2008 and 2014. Propensity score matching was used to account for potential selection bias between patients with HPV positive and negative disease. Multivariable Cox regression was used to determine the association between HPV status and OS. Kaplan-Meier methods were used to compare actuarial survival estimates. Results: We identified 5927 patients with tumor HPV status for this analysis, 3523 (59.4%) had HPV positive disease and 2404 (40.6%) had HPV negative disease. Propensity-matched analysis demonstrated that patients with HPV positive locally advanced (T3-4 or node positive) anal cancer had better OS (HR = 0.81 (95%CI: 0.68-0.96), p=.018). For patients with early stage disease (T1-2 and node negative) there was no difference in OS (HR = 1.11 (95%CI: 0.86-1.43), p=.43). In the unmatched cohort, we found a significant improvement...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research

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AbstractIn the U.S. there is an epidemic of sexually transmitted diseases (STIs). One of the most prevalent STIs is the Human Papillomavirus (HPV). Certain high risk strains of HPV are believed to cause virtually all cervical cancers, over 90% of anal cancers, 70% of oropharyngeal cancers, and the majority of anal  genital warts. HPV is preventable through vaccination and is available for both men and women. Several educational interventions have been employed, yet baseline awareness and knowledge related to HPV and 9vHPV remains relatively low among young men. What is not known is the most effective method for provid...
Source: Journal of Community Health - Category: International Medicine & Public Health Source Type: research
ConclusionsPractitioners who provide care for PLWH are proactive in screening to help prevent and control anal cancer, a rare and slow-growing disease. Continuing to regularly surveil high-risk populations, particularly PLWH previously diagnosed with high-grade lesions, is critical to prevent and control anal cancer.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
By Jacqueline Howard, CNN (CNN) — The US Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, known as ACIP, voted unanimously on Wednesday to recommend HPV vaccines for both boys and girls and men and women through age 26. Previously the CDC recommended that teen girls and young women who had not been adequately vaccinated receive the human papillomavirus vaccine through age 26, but the recommendation for teen boys and young men only went through age 21. The CDC’s recommendation that children start receiving two doses of the HPV vaccine around 11 or 12...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN HPV vaccine Source Type: news
Recently, Desperate Housewives star Marcia Cross made headlines by discussing her diagnosis of anal cancer and her husband ’s diagnosis of throat cancer, revealing that both had been related to the human papillomavirus, or HPV. The move was brave, as the actress broke free from the stigma related to anal cancer and sexually transmitted diseases. More […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
Anal cancer, a rare cancer often caused by the human papillomavirus (HPV) has been brought to the forefront as an actress shares her story of her own experience with this disease. HPV vaccination will reduce risk of HPV-related cancers in the future.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Actress Marcia Cross has been public about her anal cancer diagnosis more than a year ago, now sharing that doctors suspect her cancer came from the same type of human papillomavirus, or HPV, behind her husband's throat cancer.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
There is a vaccine that can prevent persistent infection with the human papillomavirus (HPV), the etiological agent in many HPV-related cancers worldwide and within the United States. Globally, approximately 570,000 females and 60,000 males are diagnosed annually with a cancer that is related to the HPV.1 More than 90% of all cases of cervical and anal cancers are caused by persistent infection with the HPV, and it causes 75% of all cases of vaginal cancer, 70% of all cases of oropharyngeal and vulvar cancer, and 60% of penile cancer.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Quality Care for Women ’s Health Source Type: research
Introduction: Anal cancer screening has not been adopted by Taiwanese care providers. The study aim was to explore the differences of anal cytology and HPV detection among men with and without HIV.Methodology: In this case-control study, men with HIV who attended one of the outpatient clinics of Taoyuan General Hospital were enrolled as cases. Men who had experienced condomless sex and tested HIV negative were enrolled as controls. Anal swabs were collected for thin-preparation anal cytology and HPV genotyping.Results: A total of 288 men who had tested positive for HIV and 208 who had tested HIV negative were enrolled; 75%...
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
ConclusionsFuture interventions should push for a stronger role of providers (e.g., gynecologists) in anal health, education, and screening. Additionally, campaigns should be crafted to promote the ASE as an easy, at-home screening tool that could trigger an early warning for anal disease.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
BACKGROUND: Data on tissue distribution of human papillomavirus types in anal high-grade squamous intraepithelial lesions are limited and the impact on treatment outcomes poorly understood. OBJECTIVE: We aimed to investigate potential predictors of treatment failure after electrocautery ablation, including human papillomavirus type(s) isolated from index lesions. DESIGN: This was a retrospective cohort study. SETTINGS: The study was conducted at a tertiary academic referral center in New York City. PATIENTS: Seventy-nine HIV-infected patients with a diagnosis of anal high-grade squamous intraepithelial lesion...
Source: Diseases of the Colon and Rectum - Category: Gastroenterology Tags: Original Contribution: Colorectal Cancer Source Type: research
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