Crosstalk between adipose tissue insulin resistance and liver macrophages in Non Alcoholic Fatty Liver Disease

The recent epidemic in chronic liver disease is related to the burden of Non-Alcoholic Fatty Liver Disease (NAFLD), paralleling the worldwide increase of obesity. [1] NAFLD is a complex condition related to metabolic derangements in insulin resistance (IR), but in a subset of patients the liver becomes the target of multiple hits leading to Non-Alcoholic SteatoHepatitis (NASH), the histological phenotype that may progressively develop liver fibrosis, cirrhosis and possibly hepatocellular carcinoma.

Source: Journal of Hepatology - July 9, 2019 Category: Gastroenterology Authors: Chiara Rosso, Konstantin Kazankov, Ramy Younes, Saeed Esmaili, Milena Marietti, Marco Sacco, Fabrizia Carli, Melania Gaggini, Federico Salomone, Holger Jon M øller, Maria Lorena Abate, Hendrik Vilstrup, Amalia Gastaldelli, Jacob George, Henning Grønbæk Source Type: research