New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.

New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy. 2019 Jul 09;:1-14 Authors: Larabi A, Barnich N, Nguyen HTT Abstract One of the most significant challenges of inflammatory bowel disease (IBD) research is to understand how alterations in the symbiotic relationship between the genetic composition of the host and the intestinal microbiota, under impact of specific environmental factors, lead to chronic intestinal inflammation. Genome-wide association studies, followed by functional studies, have identified a role for numerous autophagy genes in IBD, especially in Crohn disease. Studies using in vitro and in vivo models, in addition to human clinical studies have revealed that autophagy is pivotal for intestinal homeostasis maintenance, gut ecology regulation, appropriate intestinal immune responses and anti-microbial protection. This review describes the latest researches on the mechanisms by which dysfunctional autophagy leads to disrupted intestinal epithelial function, gut dysbiosis, defect in anti-microbial peptide secretion by Paneth cells, endoplasmic reticulum stress response and aberrant immune responses to pathogenic bacteria. A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approaches for disease management. Abbreviations: AIEC: adherent-invasive Escherichia coli; AMPK: AMP-activated protein kinase; AT...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research

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This study paves the way to isotopomics of other steroids and similar molecular weight compounds. PMID: 31627808 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
J. Mater. Chem. A, 2019, Advance Article DOI: 10.1039/C9TA06877E, PaperQidi Wang, Chenglong Zhao, Xiaohui Lv, Yaxiang Lu, Kui Lin, Shaoqiong Zhang, Feiyu Kang, Yong-Sheng Hu, Baohua Li Exploring synergy effects of the composite metal anode and electrolyte modification as an effective strategy to fabricate ultra-stable Na-metal batteries. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01647C, CommunicationLijun Zong, Yufeng Han, Lei Gao, Chao Du, Xiaopan Zhang, Lin Li, Xiao Huang, Jinhua Liu, Hai-Dong Yu, Wei Huang This communication describes a rational design of transparent paper-based biosensing platform for multi-target detection by wavelength-dependent absorbance/transmittance. The platform was successfully applied in examination of protein and cholesterol in serum... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
ConclusionThe NPCQLQ-C and NPCQLQ-A are the first disease-specific QoL scales to be developed for people living with NPC. This novel approach to scale development values the experiential, real life impact of living with NPC and focused on the lived-experiences and impact on QoL. The scales will enable healthcare professionals and researchers to have a better understanding and quantifiable measurement of the impact of living with NPC on a patient ’s daily life.
Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThe experience of changes in taste was common yet highly variable in its presentation and resultant changes in food preferences. Taste changes did not always resolve soon after treatment completion. Future research should identify ways to manage this symptom in pediatric cancer patients.
Source: Quality of Life Research - Category: Health Management Source Type: research
Shaggy aorta is defined by diffuse, ulcerated plaques arising in the descending thoracic aorta and often extending through the abdominal and visceral segment. Two types of emboli originating from atherosclerotic plaques can be distinguished: thromboemboli and atheroemboli (cholesterol crystal emboli). These plaques may lead to visceral, pelvic, or peripheral embolization syndromes and have been shown to be associated with a higher 30- day mortality after endovascular aneurysm repair (EVAR) and open aortic repair (OAR).
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The objective of this study was to report on long-term survival of major lower limb amputees after rehabilitation as well as to identify factors leading to poorer survival.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Publication date: Available online 19 October 2019Source: Autoimmunity ReviewsAuthor(s): Andrea Rubbert-Roth, Melinda Zsuzsanna Szabó, Melinda Kedves, György Nagy, Fabiola Atzeni, Piercarlo Sarzi-PuttiniAbstractThe five TNF inhibitors currently approved for the treatment of RA are characterised by differences in their molecular structures, half-lives, administration routes, dosing intervals, immunogenicity, and use in women who wish to become pregnant. TNF inhibitors still represent the first biologic after conventional synthetic DMARD (csDMARD) in the majority of patients according to registry data. This was p...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Publication date: Available online 19 October 2019Source: Stem Cell ResearchAuthor(s): Marija Dulovic-Mahlow, Agnieszka Lukomska, Sokhna Haissatou Diaw, Alexander Balck, Max Borsche, Karen Grütz, Insa Lenz, Franziska Rudolph, Katja Lohmann, Christine Klein, Philip SeiblerAbstractDespite a genetic component in the development of Parkinson´s disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus a...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 19 October 2019Source: Stem Cell ResearchAuthor(s): Chuti Laowtammathron, Pimonwan Srisook, Pimjai Chingsuwanrote, Nittaya Jiamvoraphong, Supaporn Waeteekul, Papussorn Terbto, Yaowalak U-Pratya, Chanchao Lorthongpanich, Surapol IssaragrisilAbstractCD34+ cells were isolated from mobilized peripheral blood of a healthy donor and reprogrammed by nucleofection with episomal plasmids carrying L-MYC, LIN28, OCT4, SOX2, KLF4, EBNA-1, and shRNA against p53. The obtained MUSIi012-A cell line maintained the pluripotent phenotype, the ability to differentiate into all three germ layers, and a normal karyotype.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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