Pseudo-bipolar spindle formation and cell division in postnatal binucleated cardiomyocytes

The majority of adult human, mouse and rat cardiomyocytes is not diploid mononucleated. Nevertheless, the current literature on heart regeneration based on cardiomyocyte proliferation focuses mainly on the proliferation capacity of diploid mononucleated cardiomyocytes, instead of the more abundant mononucleated polyploid or binucleated cardiomyocytes. Here, we aimed at a better understanding of the process of mitosis and cell division in postnatal binucleated cardiomyocytes.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Short communication Source Type: research