Babesiosis Vaccines: Lessons Learned, Challenges Ahead, and Future Glimpses.

Babesiosis Vaccines: Lessons Learned, Challenges Ahead, and Future Glimpses.
Trends Parasitol. 2019 Jul 04;:
Authors: Rathinasamy V, Poole WA, Bastos RG, Suarez CE, Cooke BM
Abstract
The incidence and prevalence of babesiosis in animals and humans is increasing, yet prevention, control, or treatment measures remain limited and ineffective. Despite a growing body of new knowledge of the biology, pathogenicity, and virulence of Babesia parasites, there is still no well-defined, adequately effective and easily deployable vaccine. While numerous published studies suggest that the development of such anti-Babesia vaccines should be feasible, many others identify significant challenges that need to be overcome in order to succeed. Here, we review historic and recent attempts in babesiosis vaccine discovery to avoid past pitfalls, learn new lessons, and provide a roadmap to guide the development of next-generation babesiosis vaccines.
PMID: 31281025 [PubMed - as supplied by publisher]

Source: Trends in Parasitology - July 3, 2019 Category: Parasitology Authors: Rathinasamy V, Poole WA, Bastos RG, Suarez CE, Cooke BM Tags: Trends Parasitol Source Type: research