Whole-genome analysis of rotavirus G4P6 strains isolated from Korean neonates: association of Korean neonates and rotavirus P6 genotypes

ConclusionsThis study showed that the whole-genome constellation of rotavirus G4P[6] strains from Korean neonates resembled a Wa-like genotype constellation. Additionally, rotavirus genotypes detected in Korean neonates had unique P[6] sequences, which may be the cause of Korean neonatal rotavirus infection.
Source: Gut Pathogens - Category: Microbiology Source Type: research

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Rotavirus vaccination has substantially reduced the incidence of rotavirus-associated gastroenteritis (RVGE) in high-income countries, but vaccine impact and estimated effectiveness are lower in low-income countries for reasons that are poorly understood. We used mathematical modeling to quantify rotavirus vaccine impact and investigate reduced vaccine effectiveness, particularly during the second year of life, in Malawi, where vaccination was introduced in October 2012 with doses at 6 and 10 weeks. We fitted models to 12 years of prevaccination data and validated the models against postvaccination data to evaluate the mag...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Publication date: Available online 12 August 2019Source: Molecular and Cellular ProbesAuthor(s): Shuo Jia, Baohua Feng, Zhuo Wang, Yingying Ma, Xuwen Gao, Yanping Jiang, Wen Cui, Xinyuan Qiao, Lijie Tang, Yijing Li, Li Wang, Yigang XuAbstractCurrently in China, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine rotavirus (PoRV), and porcine deltacoronavirus (PDCoV) are the major causes of porcine viral diarrhea, and mixed infections in clinics are common, resulting in significant economic losses in pig industry. Here, a dual priming oligonucleotide (DPO)-based multiplex real-time SY...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: Available online 31 July 2019Source: Computational and Structural Biotechnology JournalAuthor(s): Mary Hauser, William J. Dearnaley, A. Cameron Varano, Michael Casasanta, Sarah M. McDonald, Deborah F. KellyAbstractRotavirus is a well-studied RNA virus that causes severe gastroenteritis in children. During viral entry, the outer layer of the virion is shed, creating a double-layered particle (DLP) that is competent to perform viral transcription (i.e., mRNA synthesis) and launch infection. While inactive forms of rotavirus DLPs have been structurally characterized in detail, information about the transcrip...
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Abstract Diarrhea remains one of the top five causes of disease and death among young children in developing nations. Fortunately, scientists are making progress developing vaccines against enterotoxigenic E. coli (ETEC) and Shigella, two of the leading diarrhea pathogens. As vaccine developers start to consider field efficacy trials of these vaccines, they should be aware of the importance of evaluating not only vaccine direct effects on the immunized, but also the herd effects that vaccination can afford to the unimmunized in a community. In a workshop held at the conference titled "Vaccines against Shigell...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Abstract Enteric viruses are present in the environment as a result of the discharge of poorly or untreated wastewater. The spread of enteric viruses in the environment depend to human activities like stools of infected individuals ejected in the external environment can be transmitted by water sources and back to susceptible individuals for other cycles of illness. Among the enteric viruses Rotaviruses (RV) and Hepatitis A viruses (HAV) is the most detected in wastewater causing gastroenteritis and acute hepatitis. Therefore, it is of interest to climate change, mainly temperature and carbon Dioxide (CO2) variati...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
K. C. Jere et al.
Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
by Joseph A. Lewnard, Benjamin A. Lopman, Umesh D. Parashar, Aisleen Bennett, Naor Bar-Zeev, Nigel A. Cunliffe, Prasanna Samuel, M. Lourdes Guerrero, Guillermo Ruiz-Palacios, Gagandeep Kang, Virginia E. Pitzer Cohort studies, randomized trials, and post-licensure studies have reported reduced natural and vaccine-derived protection against rotavirus gastroenteritis (RVGE) in low- and middle-income countries. While susceptibility of children to rotavirus is known to vary within and between settings, impli cations for estimation of immune protection are not well understood. We sought to re-estimate naturally-acquired protect...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
Condition:   Rotavirus Infection of Children Interventions:   Biological: TV P2-VP8;   Biological: Rotarix Sponsors:   PATH;   Bill and Melinda Gates Foundation;   SK Bioscience Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(SENeo) y del Comité Asesor de Vacunas de la Asociación Española de Pediatría (CAV-AEP) Abstract Rotavirus (RV) is the leading cause of severe acute gastroenteritis in infants worldwide. Most children are infected by RV by the age of 5years, and especially in the first 2years. Two oral attenuated vaccines against RV are licensed in industrialised countries, which have proven to be safe and effective against the disease. The main objective of these vaccines has been to reproduce the natural history of infection and protect against severe disease in the first months of life. Preterm infan...
Source: Anales de Pediatria - Category: Pediatrics Authors: Tags: An Pediatr (Barc) Source Type: research
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