Candidalysin: discovery and function in Candida albicans infections.

Candidalysin: discovery and function in Candida albicans infections. Curr Opin Microbiol. 2019 Jul 06;52:100-109 Authors: Naglik JR, Gaffen SL, Hube B Abstract Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease. PMID: 31288097 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

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Rezafungin (RZF) is a novel echinocandin in development for prevention of invasive fungal disease caused by Candida, Aspergillus, and Pneumocystis species in patients undergoing blood and marrow transplantation. RZF has a favorable safety and tolerability profile, a low risk of drug-drug interactions and with its stability, pharmacokinetics that allow for once-weekly dosing with broad distribution to the lung and other fungal target organs.We previously demonstrated RZF efficacy in preventing Pneumocystis infection in an immunosuppressed mouse model.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 502 Source Type: research
AbstractIn a search for novel therapeutic agents against pathogenic fungal species,Candida in addition to bacterial species, novel spinel nanoferrites were assayed against four pathogenic fungi isolated from different clinical samples of ear and skin infections:Aspergillus flavus, A. niger, A. terrus and A. fumigatus, fourCandia species:Candida albicans, C. parapsilosis, C. krusei andC. tropicales, and four bacterial species: two Gram +ve:Bacillus subtilis andStreptococcus pyogenes, and two Gram −ve:Pseudomonas vulgaris andEscherichia coli. It was found that the assayed compounds displayed different levels of antifun...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
This study explore the in silico and in vitro comparative analysis of cofactor NADP binding mechanism in rossmann fold of isolated M. caribbica and other xylose fermenting Debaryomycetaceae family yeast. The rossmaan fold analysis of M. caribbica and Debaryomycetaceae family of yeast revealed, xylose fermenting organisms Scheffersomyces stipitis, Debaryomyces hansenii, Debaryomyces nepalensis, Candida parapsilosis, Candida maltose has divergence structure of rosmann fold. Whereas M. caribbica and Calamus tenuis has unique structure of rossmann fold. Also, the identified rossmann fold of Debaryomycetaceae family yeast and i...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
"Clinical Aspects of Chronic Granulomatous Disease in Upper Egypt". Immunol Invest. 2020 Jan 22;:1-13 Authors: El-Mokhtar MA, Salama EH, Fahmy EM, Mohamed ME Abstract Chronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency disorder that affects phagocytes and is characterized by a marked increased susceptibility to severe bacterial and fungal infections. We aimed to describe the clinical presentations of pediatric patients with CGD in Upper Egypt and to identify the defective component of NADPH oxidase. Pediatric patients diagnosed with CGD within one year from Januar...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Publication date: February 2020Source: Journal of Vascular and Interventional Radiology, Volume 31, Issue 2Author(s): Ricardo Miguel Costa de Freitas, José Guilherme Mendes Pereira Caldas, Silvia Mazzali Verst, Ana Oliveira Hoff, João Evangelista Bezerra Neto, Maria Candida Barisson Villares Fragoso
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsA disproportionately high burden ofC.trachomatis is present among young asymptomatic women in Fiji of iTaukei ethnicity despite the low number of lifetime partners. Syndromic management and lack of barrier contraceptives contribute to hyperendemic levels. Strategic STI education and screening of at-risk adolescents, young women, and their partner(s) with appropriate treatment are urgently needed to control the epidemic.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Fungal infections, widespread throughout the world, affect a broad range of life forms, including agriculturally relevant plants, humans, and insects. In defending against fungal infections, the fruit fly Drosophila melanogaster employs the Toll pathway to induce a large number of immune peptides. Some have been investigated, such as the antimicrobial peptides (AMPs) and Bomanins (Boms); many, however, remain uncharacterized. Here, we examine the role in innate immunity of two related peptides, Daisho1 and Daisho2 (formerly IM4 and IM14, respectively), found in hemolymph following Toll pathway activation. By generating a C...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: 21 January 2020Source: Cell Reports, Volume 30, Issue 3Author(s): Sergio D. Moreno-Velásquez, Su Hlaing Tint, Valentina del Olmo Toledo, Sanda Torsin, Sonakshi De, J. Christian PérezSummaryIntegrating nutrient sensing with the synthesis of complex molecules is a central feature of metabolism. Yet the regulatory mechanisms underlying such integration are often unknown. Here, we establish that the transcription regulators Rtg1/3 are key determinants of sphingolipid homeostasis in the human fungal pathogen Candida albicans. Quantitative analysis of the C. albicans lipidome reveals Rtg1/3-d...
Source: Cell Reports - Category: Cytology Source Type: research
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b01561
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
zdag Papp Kőszegi We investigated the antifungal activities of purified plant metabolites artemisinin (Ar) and scopoletin (Sc) including inhibition, effects on metabolic activities, viability, and oxidative stress on planktonic forms and on preformed biofilms of seven Candida species. The characteristic minimum inhibitory concentration (MIC90) of Ar and Sc against Candida species ranged from 21.83–142.1 µg/mL and 67.22–119.4 µg/mL, respectively. Drug concentrations causing ≈10% CFU decrease within 60 minutes of treatments were also determined (minimum effective c...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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