PET Imaging of Adenosine Receptors in Diseases.

PET Imaging of Adenosine Receptors in Diseases.
Curr Top Med Chem. 2019 Jul 08;:
Authors: Li J, Hong X, Li G, Conti PS, Zhang X, Chen K
Abstract
Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, and A3R. Alterations of ARs function and expression have been studied in neurological diseases (epilepsy, Alzheimer's disease, and Parkinson's disease), cardiovascular diseases, cancer, and inflammation and autoimmune diseases. A series of positron emission tomography (PET) probes for imaging ARs have been developed. The PET imaging probes have provided valuable information for diagnosis and therapy of diseases related to alterations of ARs expression. This review presents a concise overview of various ARs-targeted radioligands for PET imaging in diseases. The most recent advances in PET imaging studies by using ARs-targeted probes are briefly summarized.
PMID: 31284861 [PubMed - as supplied by publisher]

Source: Current Topics in Medicinal Chemistry - July 7, 2019 Category: Chemistry Authors: Li J, Hong X, Li G, Conti PS, Zhang X, Chen K Tags: Curr Top Med Chem Source Type: research