Synthesis, characterization, quantum chemical calculations and antioxidant activity of new bis-isatin carbohydrazone and thiocarbohydrazone derivatives

Publication date: Available online 4 July 2019Source: Journal of Molecular StructureAuthor(s): Halit Muğlu, M. Serdar Çavuş, Temelkan Bakır, Hasan YakanAbstract1,5-Bis(5-chloro-2-oxoindolin-3-ylidene)thiocarbohydrazone (3), 1,5-Bis(5-metoxy-2-oxoindolin-3-ylidene)thiocarbohydrazone (4), 1,5-Bis(5-metoxy-2-oxoindolin-3-ylidene)carbohydrazone (5) were obtained from isatins and thio/carbohydrazides under reflux in absolute ethanol. The structures of these synthesized compounds were determined using FT-IR, 1H NMR, 13C NMR spectroscopy, and elemental analysis. Quantum chemical calculations were also performed at B3LYP/6-311++G(2d,2p) level in order to obtain information about the molecular geometries and electronic data, such as HOMO-LUMO energy eigenvalues and density of states (DOSs). In addition, structural and antioxidant properties of the compounds were studied theoretically. QTAIM analysis was performed to investigate the relationship between intramolecular interactions, electronic data and antioxidant activity. The in vitro antioxidant activity of all the compounds was determined by 1,1-Diphenyl-2-Picryl Hydrazyl (DPPH) free radical scavenging method. Antioxidant activity was followed by Ascorbic acid> 3 > 4> 5.Graphical abstractNew bis-isatin carbohydrazone and thiocarbohydrazone derivatives were synthesized. The structures were determined using FT-IR, 1H NMR, 13C NMR spectroscopy, and elemental analysis spectroscopic methods. The synthesized compoun...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research

Related Links:

An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history of renal disease.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Make Your Diagnosis Source Type: research
New international consensus guidelines offer recommendations for selecting adults with gastroesophageal reflux disorder (GERD) for antireflux surgery.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: General Surgery News Source Type: news
DiscussionWe suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease that develop terminal pulmonary consequences and require a lung transplant.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusions: Fundoplication with GT is effective in reducing hospital admissions and emergency department visits from GER and seizures in NI children. Because of high mortality within a year of fundoplication and GT in DNR children, anti-reflux medications with GT might be an alternative. PMID: 31423518 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
We examined the relationships among symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BMI).
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
ConclusionsPatient and physician ’s characteristics were related to high utilization of gastroenterology services among GERD patients. The associations with age and country of birth might reflect more severe disease. The regional differences warrant further research and interventions at the district level. Training in gastroenter ology of primary care physicians without a board certification is warranted.
Source: Israel Journal of Health Policy Research - Category: International Medicine & Public Health Source Type: research
MONDAY, Aug. 19, 2019 -- Symptomatic gastroesophageal reflux disease (GERD) is associated with chronic temporomandibular disorder (TMD), and the correlation is partially mediated by somatization, anxiety, and undermined sleep, according to a study...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
CONCLUSIONS The study demonstrates that aspiration of gastric contents can cause pulmonary fibrosis, and mixed aspiration of pepsin and gastric fluid can accelerate this process. This study provides strong evidence in support of a potential association between human GERD and IPF. PMID: 31419218 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
The objective of this article is to provide a structured and applicable approach to managing ESRD that is up-to-date and evidence based. To achieve this objective, we created an alphabetized mnemonic and synthesized our discussion to address Anemia, Bone health, Cardiovascular issues, vitamin D deficiency, Electrolytes imbalances, Fluid overload, and Gastroesophageal reflux in patients with ESRD.
Source: The Journal for Nurse Practitioners - Category: Nursing Authors: Tags: Feature Article Source Type: research
More News: Acid Reflux | Antidoxidants | Chemistry | Gastroesophageal Reflux Disease | GERD | Molecular Biology | Vitamin C