Modulating Nanoparticle Translocation by Surface Chemistry of Gold Nanopores

Publication date: July 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 7Author(s): Ao-Xue LIU, Dan YANG, Hong-Na LI, Guo-Hui LIU, Qiang FU, Yu-Ping SHAN, Guo-Cheng YANG, Jin HEAbstractA simple and effective method for modulating nanoparticles (NPs) translocation through nanopore by tuning the surface change of chemically modified gold coated nanopore was developed. The gold-coated pore is simply prepared from a nanopipette and the partially insulated gold coating can be utilized to effectively concentrate NPs near the nanopore entrance. The surface modification of gold near the orifice effectively modulates the NP translocation behavior, mainly through electrostatic force and chemical interactions. This system can be extended to the detection of biological entities, such as virus and exosomes which have similar size of NPs.Graphical abstractAfter wax insulation, the gold coated nanopipette demonstrates nice electrochemical properties of nanoelectrode. The surface modification of gold near the orifice effectively modulates the NP translocation behavior, manly through electrostatic force and chemical interactions. In the next step, this method can be applied to protein, DNA, and other single molecules.
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research