Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus.

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus. Exp Ther Med. 2019 Jul;18(1):685-691 Authors: Li H, Dong A, Lv X Abstract Correlation between expression levels of advanced glycation end products (AGEs) and adipocytokines and oxidative stress index malondialdehyde (MDA) in placental tissues of pregnant women with gestational diabetes mellitus (GDM) was investigated. Seventy-two cases of GDM pregnant women who received routine prenatal examination and gave birth in the Department of Obstetrics, Binzhou City Center Hospital from March 2016 to May 2017 were collected as the observation group. Another 80 cases of normal pregnant women who gave birth at the same time were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of AGEs, visfatin, APN and IL-6 in the lysate of placental tissues. MDA levels were measured by thiobarbituric acid method. Correlation of expression levels of AGEs, visfatin, APN, IL-6 and MDA were analyzed. The expression level of MDA in placental tissues of the observation group was significantly higher than that of the control group (t=16.44, P
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research

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Antenatal depression is becoming one of the most common complications during pregnancy, affecting up to 10% of pregnant women (Vigod  et al., 2016). Higher rates were reported in Chinese pregnant women (Lau et al., 2011; Li et al., 2012a). Depression during pregnancy may lead to adverse maternal outcomes, such as gestational diabetes mellitus, hypertension, preeclampsia (Becker et al., 2016), and postpartum depression(Silva  et al., 2012), and subsequent adverse birth and postnatal outcomes, including low birth weight (Grigoriadis et al., 2013; Grote et al., 2010), prematur...
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research
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Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
In conclusion our findings indicate an association between polymorphisms FokI and Cdx-2 within VDR gene and SPTB, suggesting their involvement in the triggering of these syndromes. PMID: 29128634 [PubMed - as supplied by publisher]
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
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Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Author Affiliations open 1Department of Preventive Medicine, School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China 2Center on Clinical and Epidemiological Eye Research, Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China 3Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA 4Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA 5Channing ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Background:Symptomatic cholelithiasis occurs in pregnancy in our patient population, some of whom are diabetic. But its management remains controversial. How common is the problem? Is our current policy of management appropriate for our patients?Patients and Methods: The management of 162 pregnant patients admitted over a ten-year period with symptomatic cholelithiasis was evaluated in a retrospective study. The patients were divided into two groups: Group A, 58 patients with diabetes mellitus, and Group B, 104 nondiabetic patients.Results: Symptomatic cholelithiasis occurred in only 0.3% of our pregnant patients. Of 162 p...
Source: Annals of Saudi Medicine - Category: Journals (General) Tags: ISSUE 1-2 Source Type: research
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Conclusion This cohort study suggests that babies of women diagnosed with gestational diabetes at 28 weeks or later may have already started to grow abnormally large for their age. Not every baby was affected, but the risk of a larger baby was higher in women who developed diabetes, and the changes had happened before they were diagnosed. This increases the argument that screening for diabetes in pregnancy should be moved earlier than 28 weeks, although no differences were seen at 20 weeks, so this looked too early to be of any practical use. Current recommended practice in England and Wales suggest women with gestational ...
Source: NHS News Feed - Category: Consumer Health News Tags: Pregnancy/child Source Type: news
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Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 4.2 Sleep and Control of Breathing Source Type: research
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Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
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