Association of the blood eosinophil count with end-organ symptoms

ConclusionsThe observed U-shaped association with a plateau of risks around 1 x 109/l indicates that the risk for symptoms due to eosinophilia do not increase proportionate at higher counts. This study demonstrates for the first time that there is indeed an increased risk below median count of 0.16 x 109/l for an increased risk for the same manifestations. Clinically, it means that a normal or even low count of eosinophils do not rule out a risk for organ affection by eosinophils, and may contribute to explain, why patients may have normal eosinophil counts in e.g. asthma or allergy and still have symptoms from the lungs and skin, most likely explained by the extravasation of eosinophils.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research

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Historically, pediatric allergic diseases have been understudied, and their treatments were missing their mark. For example, not very many decades ago “parentectomy” was a viable therapeutic option when treating severe pediatric asthma. Subsequently, the concept of asthma as an inflammatory disease emerged, and we began using inhaled corticosteroids (ICS) with the thought that using them regularly would interrupt disease progression and even r everse underlying asthma. To prove this, in the early 1990s, the National Institutes of Health initiated the CAMP (“Child Asthma Management Program”) study, b...
Source: Immunology and Allergy Clinics of North America - Category: Allergy & Immunology Authors: Tags: Foreword Source Type: research
Study in African - American children shows symptom - based adjustment of inhaled corticosteroids is feasible
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Family Medicine, Pediatrics, Pharmacy, Pulmonology, Allergy, Emergency Medicine, Journal, Source Type: news
FRIDAY, Aug. 23, 2019 -- Children with mild asthma can use inhalers as needed, according to a study published online July 30 in the Journal of Allergy and Clinical Immunology: In Practice. Kaharu Sumino, M.D., from the Washington University School...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Trust for America's Health reported rising levels of obesity contributed to increased disease rates and health care costs (Levi et al., 2013). Factors associated with overweight and obesity rates include lower socioeconomic status, public insurance, and increased chronic disease rates.
Source: Journal of Pediatric Health Care - Category: Pediatrics Authors: Source Type: research
This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which r...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case report Source Type: research
Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research
ConclusionUpper and lower airway disease is often initially recognized in patients with AERD, whereas drug sensitivity presents month to years later. This delay may be due to the pathophysiology of AERD and disease progression or due to practice patterns in diagnostic testing and coding. Further work is warranted to identify these patients at early stages in their disease progression.
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. Allergic reactions to foods often occur on the first known ingestion, suggesting that exposure of offspring to food allergens may occur in utero and/or through breast milk. This creates a milieu that shapes the neonatal immune response to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Chronic urticaria (CU) is a common, heterogeneous and debilitating disease. Antihistamines and omalizumab are the mainstay therapies of CU. Additional treatment options are needed. Here, we review the off and beyond label use of licensed drugs, novel treatments that are currently under development, and promising new targets.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: CME Reviews Source Type: research
A significant proportion of primary immunodeficiency (PID) diseases include humoral deficiency. Humoral deficiencies range in severity from complete deficiencies observed in diseases such as X-linked or autosomal recessive agammaglobulinemias and certain severe combined immune deficiencies (SCID), to milder specific antibody deficiencies. According to a recent update from the Jeffrey Modell Centers Network, disorders classified as primarily humoral deficiencies accounted for 45% of survey center PID patients worldwide, not including the many additional patients with combined immune deficiencies who also suffer from antibody deficiency.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: CME Reviews Source Type: research
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