The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0950-9828 Purpose SUDOSCAN, a new non-invasive, quick, sensitive and quantitative technique, has been developed to detect diabetic peripheral neuropathy, and the latter is believed to be correlated with impaired β-cell function. The purpose of the present study was to investigate the associations between β-cell function indices and sudomotor function in Chinese type 2 diabetes. Methods A total of 266 Chinese patients with type 2 diabetes were enrolled. Sudomotor function was assessed using electrochemical skin conductance of hands and feet. Pancreatic β-cell function was determined by homeostasis model assessment of β-cell function index, early-phase β-cell function indices and total β-cell function indices. Pearson correlation analysis and multiple linear stepwise regression analysis were carried out to explore the associations between β-cell function indices and sudomotor function. Results Patients with lower early-phase β-cell function had lower electrochemical skin conductance levels of hands and feet and higher asymmetry ratio of hands and feet. Both Pearson correlation analysis and multiple linear stepwise regression analysis showed significantly positive relationships between early-phase β-cell function and electrochemical skin conductance levels of hands and feet, after controlling for potential confounders (P
AbstractAimsTo assess diabetes care delivery and prevention of short- and long-term diabetes-related complications in patients with type 2 diabetes mellitus (T2DM) in Vietnam.MethodsDiabCare Asia is an observational, non-interventional, cross-sectional study of hospital-based outpatient care for patients diagnosed with T2DM.ResultsA total of 1631 patients (mean age 62.7 years; 58.9% female) participated in the study. The percentage of patients with HbA1c
In this study, we explore the effect of taurine on preventing SCs apoptosis and its underlying mechanism. Sprague Dawley rats were treated with streptozotocin to establish the diabetes model. Rats were randomly divided into control, diabetes, taurine treatment (as giving 0.5%, 1% and 2% taurine in drinking water) groups. RSC96 cell (a rat SCs line) was used for intervention experiments in vitro. Results showed that taurine significantly corrected morphology of damaged myelin sheath and inhibited SCs apoptosis in sciatic nerve of diabetic rats. Moreover, taurine prevented apoptosis of RSC96 cells exposed to high glucose. ...
Conclusion: This study elucidated a positive correlation between increased chemerin levels and the development of some subtypes of diabetic microangiopathy. PMID: 31379940 [PubMed]
ConclusionOrthostatic Hypotension is relatively rare in our patients with type 2 diabetes and was significantly associated with nephropathy and neuropathy.
AbstractIntroductionComplications from diabetes mellitus (DM) include cardiovascular system, peripheral neuropathy (PN), and autonomic dysfunction (AD). Goal: Assess the association of silent myocardial ischemia, AD, and PN in cardiovascular asymptomatic type 2 diabetics.MethodsAs part of a multicenter project, 40 patients with type 2 DM were studied, with> 5 years of known disease and a baseline electrocardiogram non suggestive of coronary artery disease. Myocardial SPECT was performed with exercise stress test measuring corrected QT interval (QTc) and heart rate recovery (HRR) post-exercise (abnormal QTc ≥ 450 ms at rest and HRR
In conclusion, we found the DPN could undermine driving performance of participants with type 2 diabetes, and a closer accelerator-brake lateral distance (45 mm) may be an optimal choice for them to counteract such a negative influence. PMID: 31280809 [PubMed - in process]
Conclusion: More than half of the patients included in this study were found to have neuropathy, nearly half of whom presented with the severe form. The main risk factors were increasing age, increasing duration of diabetes, obesity, and hypertension. Diabetic peripheral neuropathy is underdiagnosed in northern Tanzania where screening for neuropathy is not routinely done. PMID: 31275374 [PubMed]
Findings, published inBMJ Open Diabetes Research& Care, suggest that being female, rather than low vitamin D levels, is linked to a greater risk of peripheral neuropathy in type 2 diabetes.Endocrinology Advisor
ABSTRACTDiabetes mellitus among older men has been associated with increased bone mineral density, but paradoxically increased fracture risk. Given the interactions among medication treatment, glycemic control, and diabetes ‐associated comorbidities, the relative effects of each factor remains unclear. This retrospective study includes 652,901 male Veterans age ≥65 years with diabetes and baseline hemoglobin A1c (HbA1c) value. All subjects received primary care in the Veterans Health Administration (VHA) from 2000 to 2010. Administrative data included ICD9 diagnoses and pharmacy records, and was linked to Medicare fee...
Condition: Diabetic Neuropathy Intervention: Drug: WST-057 (4% pirenzepine) Lose Dose 2mL Sponsor: WinSanTor, Inc Not yet recruiting