The Relationship Between β-cell Function Indices and Sudomotor Function in Chinese Patients with Type 2 Diabetes

Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0950-9828 Purpose SUDOSCAN, a new non-invasive, quick, sensitive and quantitative technique, has been developed to detect diabetic peripheral neuropathy, and the latter is believed to be correlated with impaired β-cell function. The purpose of the present study was to investigate the associations between β-cell function indices and sudomotor function in Chinese type 2 diabetes. Methods A total of 266 Chinese patients with type 2 diabetes were enrolled. Sudomotor function was assessed using electrochemical skin conductance of hands and feet. Pancreatic β-cell function was determined by homeostasis model assessment of β-cell function index, early-phase β-cell function indices and total β-cell function indices. Pearson correlation analysis and multiple linear stepwise regression analysis were carried out to explore the associations between β-cell function indices and sudomotor function. Results Patients with lower early-phase β-cell function had lower electrochemical skin conductance levels of hands and feet and higher asymmetry ratio of hands and feet. Both Pearson correlation analysis and multiple linear stepwise regression analysis showed significantly positive relationships between early-phase β-cell function and electrochemical skin conductance levels of hands and feet, after controlling for potential confounders (P
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Article Source Type: research

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Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
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Source: Experimental Cell Research - Category: Cytology Authors: Tags: Exp Cell Res Source Type: research
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Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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Source: International Journal of Diabetes in Developing Countries - Category: Endocrinology Source Type: research
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Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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Condition:   Diabetic Neuropathy Intervention:   Drug: WST-057 (4% pirenzepine) Lose Dose 2mL Sponsor:   WinSanTor, Inc Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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