Strong muscles, weak heart: testosterone ‐induced cardiomyopathy

AbstractExogenous anabolic androgen steroid use is associated with adverse cardiovascular outcomes. A 53 ‐year‐old bodybuilder presented with 3 months of exertional dyspnoea. Physical examination showed tachycardia and pan‐systolic murmur; an echocardiogram showed a left ventricular ejection fraction (EF) of 15%. Evaluations included normal coronary angiogram, iron panel and thyroid studies, a n egative viral panel (human immunodeficiency virus, Lyme disease, and hepatitis), and urine toxicology. He admitted to intramuscular anabolic steroid use; his testosterone level was 30 160.0 ng/dL (normal 280–1100 ng/dL). In addition to discontinuation of anabolic steroid use, he was treated wit h guideline‐directed heart failure medical therapy. Repeat echocardiogram at 6 months showed an EF of 54% and normalized testosterone level of 603.7 ng/dL. Anabolic steroid use is a rare, reversible cause of cardiomyopathy in young, otherwise healthy athletes; a high index of suspicion is requir ed to prevent potentially fatal side effects.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research

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ConclusionsThis study shows that eradication of HCV by DAAs will result in a parallel decrease in IR and improve clinical outcomes in patients with established T2DM.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionThis research is the first to clarify that iridoid glycosides and phenol compounds are the substance basis of the hepatoprotective activity of the EAFVC. Establish rapid and effective method for the determination of main seven compounds, which is vital for the quality control of V. ciliata. These main compounds could be chosen to the analytical marker of V. ciliata. The strong activity of EAFVC and its isolated compounds on relieving the drug-induced liver injury provided the further scientific data for the traditional use and deep development of this Tibetan Medicine. In addition, PASS Online prediction, an effe...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 13 July 2019Source: Journal of Food Composition and AnalysisAuthor(s): Sooriya Arachchige Sachini Jayawardana, Jayanetti Koralalage Ramani Radhika Samarasekera, Gardhi Hettiarachchige Chamari Madhu Hettiarachchi, Gooneratne Jaanaki, Mazumdar Saikat Datta, Banerjee RoopaAbstractSoluble, insoluble and total dietary fiber contents, rapidly and slowly digestible starch contents, arabinoxylans, β-glucans, fructans, resistant starch, amylose and total sugar contents, minerals and trace elements compositions and proximate compositions of three finger millet varieties, namely Ravi, Rawana an...
Source: Journal of Food Composition and Analysis - Category: Food Science Source Type: research
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Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Authors: Olschewski H, Canepa M, Kovacs G Abstract Chronic heart and lung diseases are very common in the elderly population. The combination of chronic heart failure and chronic obstructive pulmonary disease (COPD) is also common and, according to current guidelines, these patients should be treated for both diseases. In patients with heart failure, beta-blockers are very important drugs because their use is associated with significantly improved morbidity and mortality. These beneficial effects were documented in patients with and without COPD, although theoretically there is a risk for bronchoconstriction, parti...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
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Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
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Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
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Source: Materials Research Bulletin - Category: Materials Science Source Type: research
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