Strong muscles, weak heart: testosterone ‐induced cardiomyopathy
AbstractExogenous anabolic androgen steroid use is associated with adverse cardiovascular outcomes. A 53 ‐year‐old bodybuilder presented with 3 months of exertional dyspnoea. Physical examination showed tachycardia and pan‐systolic murmur; an echocardiogram showed a left ventricular ejection fraction (EF) of 15%. Evaluations included normal coronary angiogram, iron panel and thyroid studies, a n egative viral panel (human immunodeficiency virus, Lyme disease, and hepatitis), and urine toxicology. He admitted to intramuscular anabolic steroid use; his testosterone level was 30 160.0 ng/dL (normal 280–1100 ng/dL). In addition to discontinuation of anabolic steroid use, he was treated wit h guideline‐directed heart failure medical therapy. Repeat echocardiogram at 6 months showed an EF of 54% and normalized testosterone level of 603.7 ng/dL. Anabolic steroid use is a rare, reversible cause of cardiomyopathy in young, otherwise healthy athletes; a high index of suspicion is requir ed to prevent potentially fatal side effects.
Publication date: 30 August 2020Source: International Journal of Pharmaceutics, Volume 586Author(s): Yue Zhou, Ning Gu, Fang Yang
Publication date: October 2020Source: Materials Science and Engineering: B, Volume 260Author(s): Ibdal Satar, Mimi Hani Abu Bakar, Wan Ramli Wan Daud, Nazlina Haiza Mohd Yasin, Mahendra Rao Somalu, Byung Hong Kim
Publication date: Available online 11 July 2020Source: Inorganic Chemistry CommunicationsAuthor(s): Diana Thomas, Noeline B Fernandez, Manohar D Mullassery, Surya R
Publication date: Available online 11 July 2020Source: Current Opinion in Colloid &Interface ScienceAuthor(s): Giulia Mirabello, Alessandro Ianiro, Paul H.H. Bomans, Takuto Yoda, Atsushi Arakaki, Heiner Friedrich, Gijsbertus de With, Nico A.J. M. Sommerdijk
CONCLUSIONS: Screening for HBV infection at service entry would potentially reduce chronic HBV infection in the force, decrease the threat of transfusion-transmitted HBV infection in the battlefield blood supply, and lead to earlier diagnosis and linkage to care; however, applicant screening is not cost saving. Service-related incident infections indicate a durable threat, the need for improved laboratory-based surveillance tools, and mandate review of immunization policy and practice. PMID: 32648931 [PubMed - as supplied by publisher]
Publication date: 5 January 2021Source: Journal of Hazardous Materials, Volume 401Author(s): Hongyun Niu, Yongliang Yang, Weijia Zhao, Hongzhou Lv, Hui Zhang, Yaqi Cai
ConclusionsThe presentation of our patients raises the possibility that hypertrophic cardiomyopathy may be an additional feature of the clinical syndrome associated withUCHL1 mutations, and highlights the importance of cardiac follow-up and treatment in neurodegenerative disease associated withUCHL1 mutations.
CONCLUSION: OCT-A is an important tool for the diagnosis of both naïve and fibrotic CNV in BMD patients; it is a non-invasive method for the qualitative and quantitative analysis of neovascular lesions during follow-up. Our results have shown a cyclic remodeling of treated CNV in BMD patients using both PDT and IV. PMID: 32643503 [PubMed - as supplied by publisher]
Conclusion: An elevated FFA level is an independent risk factor and independent diagnostic marker for AMI. PMID: 32648769 [PubMed - as supplied by publisher]
CONCLUSION: p64MW HPC implantation in patients under dual antiplatelet therapy with or without dual platelet function inhibition has a low procedural complication rate. The early aneurysm occlusion rate is high. PMID: 32640858 [PubMed - as supplied by publisher]