A Case of Peripartum Obsessive-Compulsive Disorder: The Potential Role of Corticosteroids, Gonadal Steroids, and the Neuropeptide Oxytocin in its Pathogenesis

by David R. Spiegel, MD; Kathyrn Sommese, MD; Anastasia Turenkov, MD; and Niels Naimon, MD Drs. Spiegel, Sommese, Turenkov, and Naimon are with the Department of Psychiatry and Behavioral Sciences at Eastern Virginia Medical School in Norfolk, Virginia. Funding: No funding was provided. Disclosures: The authors have no conflicts of interest relevant to the content […] The post A Case of Peripartum Obsessive-Compulsive Disorder: The Potential Role of Corticosteroids, Gonadal Steroids, and the Neuropeptide Oxytocin in its Pathogenesis appeared first on Innovations in Clinical Neuroscience.
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Case Report Current Issue Impulse Control Disorders Psychiatry gonadal steroids obsessive-compulsive disorder (OCD) oxytocin Peripartum Source Type: research

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Authors: Martinho FP, Duarte GS, Couto FSD Abstract OBJECTIVE: To evaluate efficacy, effect on mood, and safety of deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) at different target sites. DATA SOURCES: Electronic records from databases MEDLINE, EMBASE, and CENTRAL up to November 2019 were searched. Search terms included OCD, depression, and DBS. STUDY SELECTION: Eight randomized controlled trials (RCTs) (n = 85) and 38 observational studies (case reports and case series) (n = 225) were included. DATA EXTRACTION: In RCTs, the differences in outcomes between sham and active stimulat...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: Elevated risk of eating disorders as well as of MDD, OCD, and anxiety disorders was found in international adoptees. A parallel pattern between AN and OCD was observed, which both display less elevated rates than the other diagnoses. A considerable number of biological, environmental, and societal factors have been suggested to explain the observed differences in mental health between adoptees and non-adoptees, but they remain primarily theoretical. PMID: 32452335 [PubMed - in process]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
CONCLUSIONS: Our results suggest that assessment of obsessive compulsiveness may be useful for predicting the refractoriness of ICD behaviors in planning an interventional treatment for ICD in PD. PMID: 32454490 [PubMed - as supplied by publisher]
Source: Neuro-Degenerative Diseases - Category: Neurology Authors: Tags: Neurodegener Dis Source Type: research
We report the short-term (at discharge) and long-term (up to 2 years) outcome of a multimodal inpatient treatment program that included therapist-assisted intensive CBT with adjunctive pharmacotherapy for severely ill OCD patients who are often resistant to SRIs and are either unresponsive or unable to practice outpatient CBT. METHODS: A total of 420 patients, admitted between January 2012 and December 2017 were eligible for the analysis. They were evaluated using the Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive Compulsive Scale (YBOCS), and the Clinical Global Impression (CGI) scale. All pa...
Source: Canadian Journal of Psychiatry - Category: Psychiatry Authors: Tags: Can J Psychiatry Source Type: research
CONCLUSIONS: Trials of antidepressants may be driven mainly by commercial interests, focusing on prevalent diseases and everyday problems. No one can live a full life without experiencing several of the problems for which these drugs were tested. Antidepressants, sometimes called happy pills, could be seen as the modern version of Aldous Huxley's soma pill intended to keep everyone happy in the "Brave New World". PMID: 32444565 [PubMed - as supplied by publisher]
Source: International Journal of Risk and Safety in Medicine - Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
Abstract We aimed to evaluate [3-(6-methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-0-11C-methyloxime] ([11C]ABP688) small animal positron emission tomography (μPET) as a biomarker to visualize possible longitudinal changes in metabotropic glutamate receptor 5 (mGluR5) availability in the brain of SAP90/PSD-95 associated protein 3 (Sapap3) knockout (ko) mice, showing obsessive compulsive disorder (OCD)-like behavior. METHODS: Alongside the assessment of grooming, we performed [11C]ABP688 μPET/CT imaging in wild-type (wt; n = 10) and ko (n = 11) mice both at 3 and 9 months. Using the simplified refe...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
Long after most people have returned to work, even with social distancing, wearing masks, taking extreme care to wash hands rigorously and often, avoiding crowds, and limiting time in small confined spaces, there’s still the home environment to contend with. According to some experts, it’s more likely people can contract COVID-19 at home than outdoors and in some places long suspect, such as grocery stores. Without minimizing the importance of home cleanliness, excessive home cleaning for COVID-19 can trigger anxiety. These steps can help. Make cleaning a ritual, yet don’t spend hours doing it. Rituals an...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anxiety and Panic compulsive cleaning coronavirus COVID-19 Obsessive Compulsive Disorder Spring Cleaning Source Type: blogs
AbstractThe main aim of this systematic review and meta-analysis was to calculate and compare the frequencies of obsessions and compulsions in women with obsessive-compulsive disorder (OCD) during pregnancy (OCD-P), the postpartum period (OCD-PP) and when they are neither pregnant nor postpartum (OCD-NPP). Fourteen studies were selected after applying the inclusion and exclusion criteria. The meta-analysis showed that aggressive obsessions were much more common in OCD-PP than in OCD-P and OCD-NPP and that washing/cleaning compulsions were less frequent in OCD-PP than in OCD-P and OCD-NPP. These differences were significant...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
CONCLUSION: Even though in the majority of cases there were no issues with completing ORTO-15, thematic analysis revealed several discrepancies between our participants' perceptions of the ORTO-15 items and the previously proposed diagnostic criteria for ON. The results suggest that ORTO-15 is, at best, a mediocre screening tool for ON, which is sensitive to diet but fails to have sufficient level of specificity to detect the pathological stage. More accurate instruments are needed to further research on ON. LEVEL OF EVIDENCE: V (cross-sectional descriptive study with qualitative analysis). PMID: 32445114 [PubMed...
Source: Eating and weight disorders : EWD - Category: Eating Disorders & Weight Management Authors: Tags: Eat Weight Disord Source Type: research
Publication date: Available online 19 May 2020Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Marcelo Camargo Batistuzzo, Marina de Marco e Souza, Elisa Teixeira Bernardes, Guaraci Requena, Eurípedes Constantino Miguel, Roseli Gedanke Shavitt
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
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