Nigeria: Tuberculosis - Nigeria Has 'Sixth Highest Burden Globally'

[Premium Times] Nigeria has the highest TB burden in Africa and ranks at number six in the world, the Deputy Director, National Tuberculosis and Leprosy Control Programme (NTBLCP), Ahmad Muhammad, has said.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news

Related Links:

Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium tuberculosis and Mycobacterium leprae respectively. These diseases continue to be endemic in developing countries where the cost of new medicines presents major challenges. The situation is further exacerbated by the emergence of resistance to many front-line antibiotics. A priority now is to design new antimycobacterials that are not only effective in combatting the diseases but are also less likely to give rise to resistance. In both these respects understanding the structure of drug targets in M. tuberculosis and M. leprae is crucial. In ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
ConclusionAn immunocompromised status, such as human immunodeficiency virus infection, diabetes, and immunosuppressive drugs, are risk factors for tuberculosis infection. The use of steroids in the treatment of leprosy may increase the susceptibility to develop tuberculosis. Development of rifampicin resistance secondary to monthly rifampicin in leprosy is a major concern in treating patients coinfected with tuberculosis. Despite the paucity of reports of coinfection, it is advisable to screen for tuberculosis in patients with leprosy, especially if there are respiratory or constitutional symptoms, high erythrocyte sedimen...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
[This Day] To find and treat more tuberculosis cases in Nigeria, the Institute of Human Virology Nigeria (IHVN) and the National Tuberculosis and Leprosy Control Programme (NTBLCP) have launched a mobile application for screening and notifying TB cases by private healthcare providers.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
“Don’t trade your authenticity for approval.” ~ Unknown As a nice person, I am often conflicted because sometimes I don’t enjoy being nice. Sometimes I act nice out of moral obligation or because I’m trying to be consistent with my perceived identity. Do you view yourself as “nice”? Do others describe you as “nice”? Do you always enjoy being “nice”? If you are unsure how you are perceived by others, ask friends and family to describe you. I’ve been told how nice I am all my life, by family, friends, coworkers, and even bosses. It was a huge part of my...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Personal Personality Publishers Self-Help Tiny Buddha Authenticity Being nice people pleaser personal identity Source Type: blogs
Rifamycin derivatives, such as rifampicin, have potent antibiotic activity and have long been used in the clinic as mainstay components for the treatment of tuberculosis, leprosy, and AIDS-associated mycobacterial infections. However, the extensive usage of these antibiotics has resulted in the rapid development of bacterial resistance. The resistance mechanisms mainly include mutations of the rifamycin target RNA polymerase of bacteria and enzymatic modifications of rifamycin antibiotics. One modification is the recently characterized rifamycin degradation catalyzed by Rox enzymes, which belong to the widely occurring fla...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Traveling man: the Goodwill Ambassador shares a joke with two residents of a leprosarium in Krantau, Uzbekistan during a visit in 2013.By External SourceMay 29 2020 (IPS-Partners)   Warm greetings from Sasakawa Health Foundation in Tokyo. The 100th Issue of the WHO Goodwill Ambassador’s Newsletter has been published. Read special interviews with the Goodwill Ambassador and the UN Special Rapporteur on leprosy, and check out the Timeline of all that has happened since the first issue. My Journey Continues I started this newsletter in April 2003 to share information about the fight against leprosy. This marks th...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Health Source Type: news
Discussion “Tattooing of skin via deposition of pigment particles and ink ingredients in the dermis changes normal skin into abnormal skin. Fortunately, this often causes no harm and no disease, although with important exceptions.” Tattoos can be inadvertent from road dirt, gunpowder, pencil graphite etc., but most are desired. Tattoos are common in many cultures and over time..They have been increasing in popularity in the United States over the past few years particularly with a younger, wider and more diverse population. Newsweek reported an 18-country study in 2018 which showed 46% of Americans have a tat...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Abstract Introduction: ´╗┐Pharmacological treatment of Buruli ulcer (Mycobacterium ulcerans infection; BU) is highly effective, as shown in two randomized trials in Africa.Areas covered: We review BU drug treatment - in vitro, in vivo and clinical trials (PubMed: '(Buruli OR (Mycobacterium AND ulcerans)) AND (treatment OR therapy).' We also highlight the pathogenesis of M. ulcerans infection that is dominated by mycolactone, a secreted exotoxin, that causes skin and soft tissue necrosis, and impaired immune response and tissue repair. Healing is slow, due to the delayed wash-out of mycolactone. An array of repurpo...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Expert Rev Clin Pharmacol Source Type: research
AbstractBuruli ulcer, the third most common mycobacterial disease worldwide, is caused byMycobacterium ulcerans and characterized by devastating necrotizing skin lesions. Susceptibility to Buruli ulcer is thought to depend on host genetics, but very few genetic studies have been performed. The identification of a microdeletion on chromosome 8 in a familial form of severe Buruli ulcer suggested a monogenic basis of susceptibility. The role of common host genetic variants in Buruli ulcer development has been investigated in only three candidate-gene studies targeting genes involved in mycobacterial diseases. A recent genome-...
Source: Human Genetics - Category: Genetics & Stem Cells Source Type: research
This study systematically reviewed and conducted a meta-analysis for all research aimed at developing cell-mediated immunity (CMI) and/or serology-based tests forM.ulcerans disease. Information for this review was searched through PubMed and Web of Science databases and identified up to June 2019. References from relevant articles and reports from the WHO Annual Meeting of the Global Buruli Ulcer Initiative were also used. Twelve studies beginning in 1952, that attempted to develop CMI and/or serology-based tests for the disease were identified. These studies addressed issues of specificity and sensitivity in context of an...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
More News: African Health | Leprosy | Nigeria Health | Tuberculosis