Roles of microRNAs and prospective view of competing endogenous RNAs in mycotoxicosis

Publication date: Available online 8 July 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Yuxiao Liao, Zhao Peng, Liangkai Chen, Liegang Liu, Qinghua Wu, Wei YangAbstractMycotoxins, produced by fungi, are secondary metabolites causing adverse, toxic and pathological effects on human and animals. Studies about the association between mycotoxins and microRNAs (miRNAs) were developed since miRNAs have been demonstrated to play a critical role in many developmental processes for regulating messenger RNA (mRNA). As published studies showed, dozens of miRNAs were influenced by mycotoxins, indicating that miRNAs can play important roles in the occurrence and development of mycotoxicosis. Besides, a hypothesis called competing endogenous RNA (ceRNA) was reported to indirectly modulate the expression of mRNA via miRNA response elements (MREs) to consequently regulate cell functions. As a result, four common miRNAs were focused to predict the corresponding ceRNAs based on their own characteristics and the effects of mycotoxins on them, in hope of providing potential ways or directions of miRNAs regulation for mycotoxicosis, and expanding the research field about mycotoxicosis from ceRNA.

Source: Mutation Research Reviews in Mutation Research - July 10, 2019 Category: Genetics & Stem Cells Source Type: research