Defective WNT Signaling May Protect From Articular Cartilage Deterioration – A Quantitative Mri Study On Subjects With A Heterozygous WNT1 Mutation

WNT signaling is of key importance in chondrogenesis and defective WNT signaling may contribute to the pathogenesis of osteoarthritis and other cartilage diseases. Biochemical composition of articular cartilage in patients with aberrant WNT signaling has not been studied. Our objective was to assess the knee articular cartilage in WNT1 mutation-positive individuals using a 3.0T MRI unit to measure cartilage thickness, relaxation times, and texture features.

Source: Osteoarthritis and Cartilage - July 8, 2019 Category: Rheumatology Authors: Sami Lehtovirta, Riikka E. M äkitie, Victor Casula, Marianne Haapea, Jaakko Niinimäki, Tuukka Niinimäki, Arttu Peuna, Eveliina Lammentausta, Outi Mäkitie, Miika T. Nieminen Source Type: research