In-Hospital Maternal Mortality Down in Pregnancies With Lupus
TUESDAY, July 9, 2019 -- In-hospital maternal mortality decreased from 1998 to 2015 in systemic lupus erythematosus (SLE) and non-SLE pregnancies, with a greater decline for SLE pregnancies, according to a study published online July 9 in the Annals...
We present a case of SPTCL in which granulomas are the predominant feature, composing 75%–80% of the inflammatory infiltrate. The top differential diagnoses included infectious and autoimmune etiologies. However, special stains for microorganisms were negative, and immunohistochemical analysis of the atypical lymphocytes showed a CD3+, CD8+, TIA-1+, T-cell receptor (TCR) beta+, and CD4− infiltrate with a high Ki67 proliferation index of approximately 30%. TCR gene rearrangement studies by polymerase chain reaction with confirmation by high-throughput sequencing were necessary to exclude an autoimmune etiology, ...
This study assessed the feasibility of an adhesive tape device from Dermtech, Inc to collect RNA from affected and unaffected skin and its potential to detect gene expression differences between groups.
Background: Plasmacytoid dendritic cells (pDC) produce large amounts of type I IFN (IFN-I), cytokines convincingly linked to SLE and CLE pathogenesis. BIIB059 is a humanized mAb that binds BDCA2, a pDC-specific receptor that inhibits the production of IFN-I and other inflammatory mediators when ligated. A first-in-human study was conducted to assess safety, tolerability, pharmacokinetic (PK) and pharmacodynamic (PD) effects of single BIIB059 doses in healthy volunteers (HV) and patients with SLE with active CLE disease as well as proof of biological activity and clinical response in the SLE cohort (NCT02106897).
Background: Hair and scalp involvement in systemic lupus erythematosus (SLE) can manifest as scarring alopecia, nonscarring alopecia or scalp/hair shaft changes without apparent hair loss. While trichoscopic signs in chronic cutaneous lupus are well estabished, data on SLE patients with normal-looking or nonscarring scalp are limited
Patient History: A 41-year-old female with a history of a renal transplant, secondary to Wegner ’s granulomatosis and systemic lupus erythematosus (SLE), and on systemic immunosuppression, presented with a 2 week history of painful pink crusted lesions on the right upper arm that progressed despite topical antibiotics. The patient also complained of fatigue, nausea, and diarrhea, but denied any fevers, chills or any other systemic symptoms. The patient denied triggering events, but endorsed a history of a close association with a pet canine.
Although rare, the Sister Mary Joseph Nodule is considered the most common presentation of cutaneous metastatic gastrointestinal adenocarcinoma, arising as a solitary umbilical nodule. This case represents an example of atypical, nonumbilical, metastatic pancreaticobiliary adenocarcinoma, ominously disguised as more innocuous lesions on the extremities. A 63-year-old Caucasian female with discoid lupus was referred for a 6-week history of subcutaneous nodules on the extremities. She described a long history of lipomas but noted that the current lesions were distinctly tender.
Introduction: Bullous systemic lupus erythematosus (BSLE) is a neutrophilic blistering disease associated with SLE. The pathogenesis of this disease entail autoantibodies against type VII collagen in the dermoepidermal junction.
Background: Tumid lupus erythematosus (TLE) is an idiopathic, uncommon, photosensitive subtype of cutaneous lupus erythematosus. It is rarely associated with systemic lupus erythematosus (SLE). Unlike SLE, which affects females more, TLE has equal predilection for both genders.
A 53-year-old African American female with longstanding history of systemic lupus erythematosus (SLE) presented with painful blisters on her dorsal hands. She had followed closely with rheumatology for her pre-existing SLE. At the time of presentation to dermatology her only systemic therapy was hydroxychloroquine 200 mg twice a day. Previously, mycophenolate mofetil had controlled her SLE; the patient had stopped this medication due to nausea. Examination of the bilateral dorsal hands revealed multiple tense vesicles on a noninflamed background admixed with hypopigmented, scarred macules.
Genital lesions associated with lupus erythematosus (LE) are rarely reported in the literature despite an estimated prevalence of 5% in females with systemic lupus erythematosus (SLE). Investigation of the manifestations of lupus in the genitals can improve the care of lupus patients and further our understanding of this heterogeneous disease. A 38-year-old female with systemic lupus erythematosus (SLE) presented with three weeks of painful oral and vaginal erosions. Her SLE had been well controlled on hydroxychloroquine for five years, until four months prior, when she had worsening joint pain and nephritis.