Progression of two Progressive Supranuclear Palsy phenotypes with comparable initial disability

To avoid bias and optimize statistical power of disease-modifying therapeutic trials, it is critical to include homogeneous populations with similar rate of progression over time. Patients with Progressive Supranuclear Palsy (PSP)-Parkinsonism phenotype have overall slower disease progression than those with PSP-Richardson syndrome phenotype. However, it is unclear if the progression rate of PSP-Parkinsonism is the same when the PSP-Parkinsonism converts to PSP Richardson syndrome. We aimed to determine and compare disease progression rate of patients with the two most common PSP phenotypes: PSP-Parkinsonism and PSP Richardson syndrome, participating in the TAUROS trial.

Source: Parkinsonism and Related Disorders - July 8, 2019 Category: Neurology Authors: Ali Shoeibi, Irene Litvan, Eduardo Tolosa, Teodoro del Ser, Euyhyun Lee, TAUROS Investigators Source Type: research