Biomarker Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Myalgic encephalomyelitis/chronic fatigue syndrome affects at least 2 million people in the United States. Despite its prevalence, there ’s no laboratory test for the disease, and its diagnosis is based on symptoms like exhaustion, unrefreshing sleep, and light sensitivity. For patients with this debilitating condition, getting a diagnosis is often a long and expensive process. Now, a long-awaited biomarker-based test for the myste rious disease could be on the horizon.
Source: JAMA - Category: General Medicine Source Type: research

Related Links:

Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. Fatigue is multi-faceted and broadly defined, which makes understanding the cause of its manifestations especially difficult in conditions with diverse pathology including autoimmune diseases. In general, fatigue is defined by debilitating periods of exhaustion that interfere with normal activities. The severity and duration of fatigue episodes vary, but fatigue can cau...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Larrimore C, Ramnot A, Jaghab A, Sarduy S, Guerrero G, Troccoli P, Hilton K, Bested A Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating syndrome of unknown origin, characterized by profound postexertional malaise and fatigue, unrefreshing sleep, cognitive impairments, immune dysfunction, pain, autonomic dysfunction, and neuroendocrine symptoms. Although ME/CFS is well documented within the medical literature, it remains difficult to diagnosis and manage. Some of the current challenges include an absence of diagnostic markers, differing diagnostic criteria, and an overal...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
BACKGROUND: The combat naval vessels require continuous operational preparedness for guarding the vast coastline. Sailors onboard these ships are at risk for sleep deprivation. Sailors may be vulnerable to chronic fatigue; and decreased performance, vigila...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
ConclusionsNon-specific symptoms including headache, fatigue and dizziness feature prominently in serious AE reports from females in Denmark. Our analysis identified a cluster of reports, likely media stimulated, with a focus on symptoms of CFS and POTS. PMID: 31088598 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
Rui Yan1, ShiWan Tao1, HaiYan Liu1, Yu Chen1, JiaBo Shi1, YuYin Yang1, RongXin Zhu1, ZhiJian Yao1,2* and Qing Lu3,4*1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China2Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing, China3School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China4Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaBackground: Major depressive disorders often involve somatic symptoms and have been found to have fundamental differences from non-somatic depressi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Zoe M. Tapp, Jonathan P. Godbout and Olga N. Kokiko-Cochran* Department of Neuroscience, Institute for Behavioral Medicine Research, College of Medicine, The Ohio State University, Columbus, OH, United States Each year approximately 1.7 million people sustain a traumatic brain injury (TBI) in the US alone. Associated with these head injuries is a high prevalence of neuropsychiatric symptoms including irritability, depression, and anxiety. Neuroinflammation, due in part to microglia, can worsen or even cause neuropsychiatric disorders after TBI. For example, mounting evidence demonstrates that microglia become &ld...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionOur study shows that although the sailors are not getting sufficient restorative sleep while sailing as compared to non-sailing days, this is not affecting their cognitive functioning while working.
Source: Medical Journal Armed Forces India - Category: General Medicine Source Type: research
AbstractThe chronic fatigue syndrome (CFS) is characterized by a prolonged incapacitating fatigue, headaches, sleep disturbances, and decreases in cognition, besides alterations in other physiological functions. At present, no specific biological markers have been described in this pathology. In the present study, we analyzed in lymphocytes the CD57 expression for the diagnosis of CFS, evaluating both the percentage of blood lymphocytes expressing CD57 and the average amount of the molecule expressed per cell. The study demonstrated a marked and significant decrease in the expression of CD57 in lymphocytes of CFS patients ...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
CONCLUSIONS: At the moment, ozone therapy seems a treatment that, also because without any side effect, is possible to be proposed to patients with fibromyalgia that are not obtaining adequate results from other available treatments and it can be considered as complementary/integrative medicine. PMID: 30840304 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: February 2019Source: Brain, Behavior, and Immunity, Volume 76, SupplementAuthor(s): N.G. Klimas, M.A. Fletcher, M.M. Abreu, K. Aenlle, T. Craddock, G. BroderickA model of pathogenesis of ME/CFS and GWI includes genetic predisposition and presence of a triggering event such as exposure (GWI) or infection (ME/CFS). Important mediators of disease include autonomic, endocrine, neuroendocrine, sleep, psychosocial, immune, viral reactivation or persistence, as well as other antigenic exposures (e.g. microbiome). We’ve found immune abnormalities in ME/CFS which consist of several types of immune activation...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
More News: Chronic Fatigue Syndrome | General Medicine | Laboratory Medicine | Sleep Disorders | Sleep Medicine | USA Health