New blood test for human TB may also identify people at most risk

(National Institute for Health Research) A new study conducted by researchers in Leicester and Nottingham has shown the potential for a new blood test to not only diagnose human tuberculosis (TB) but also identify those at most risk of developing the disease, according to findings published in medical journal Clinical Infectious Diseases.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Publication date: Available online 24 September 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Swanandi Pote, Sangita Kachhap, Nicholas J. Mank, Leily Daneshian, Vincent Klapper, Sarah Pye, Amy K. Arnette, Linda S. Shimizu, Tomasz Borowski, Maksymilian Chruszcz
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
No abstract available
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Images in Interventional Pulmonology Source Type: research
Abstract The human-adapted strains of the Mycobacterium tuberculosis complex (MTBC) comprise seven phylogenetic lineages originally associated with their geographical distribution. Here, we report the genomes of three drug-resistant clinical isolates of the Latin American-Mediterranean (LAM) family collected in Kazakhstan. We utilised whole-genome sequencing to study the distribution and drug resistance of these isolates. Phylogenetic analysis grouped the genomes described in this study with the sequences from Russia, Uzbekistan, and Kazakhstan belonging to the LAM family. One isolate has acquired extensive drug r...
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
Authors: Seddon JA, Johnson S, Palmer M, van der Zalm MM, Lopez-Varela E, Hughes J, Schaaf HS Abstract Introduction An estimated 30,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, with only a small proportion diagnosed and treated. This field has historically been neglected due to a perception that children with MDR-TB are challenging to diagnose and treat. Diagnostic and therapeutic developments in adults have improved paediatric management, yet further paediatric-specific research and wider implementation of evidence-based practices are required. Areas covered This review combines the ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
[WHO] Abuja -- "During a tuberculosis outreach in my community, one of the team members insisted I take a test as he said I already have symptoms. As I was about to undergo the test, the DSNOs suggested I also undergo a COVID-19 test because I was also displaying some of the symptoms," says 32 year old Janet Ishaya, reached through the TB intervention in Kaduna State.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
[This Day] Abuja -- The federal government yesterday lamented the frequency of carnages caused by road accidents in the country, noting that deaths resulting from crashes have now exceeded the ones caused by the Human Immunodeficiency Syndrome (HIV) and the deadly tuberculosis disease combined.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
AbstractA man in his seventies who lived alone was found dead in his home. Postmortem computed tomography (CT) performed prior to autopsy showed right-sided tension pneumothorax. Autopsy revealed an active pulmonary tuberculosis (TB) lesion. Macroscopic and histopathological findings showed pleural infiltration by TB lesions, suggesting that tension pneumothorax developed in association with TB infection. Routine postmortem CT performed prior to autopsy is useful in screening for TB because the presence of TB lesions can be confirmed from characteristic pulmonary findings. However, it may be difficult to identify tuberculo...
Source: Forensic Science, Medicine, and Pathology - Category: Forensic Medicine Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
CONCLUSION: Targeted antiviral treatment and secondary recurrence prophylaxis prevent vision loss of the retina prior to immune recovery. PMID: 32966142 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Conclusions. A significant reduction in viral, fungal, and Nocardia IEps after heart transplantation was observed, most likely due to advancements in immunosuppression and preventive strategies, including pretransplant infectious diseases screening and antimicrobial prophylaxis.
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
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