Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?

Publication date: 8 July 2019Source: Cancer Cell, Volume 36, Issue 1Author(s): Stefan Mereiter, Meritxell Balmaña, Diana Campos, Joana Gomes, Celso A. ReisThis review provides insights on the impact of glycosylation in cancer biology and its influence in the current approaches of targeted cancer therapies in the clinical setting. The roles of glycosylation in cancer signaling, tumor progression, and metastasis are reviewed as well as glycans and glycan-binding proteins in tumor immunomodulation. Moreover, the latest reports on glycans influencing targeted therapeutic approaches in cancer are summarized. Finally, we discuss the future challenges of the field, outlining potential applications of glycan-based biomarkers for patient stratification and strategies for improving personalized cancer treatment.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research