How I do it: endoscopic supracerebellar infratentorial approach for torcular meningioma removal
ConclusionEndoscopic supracerebellar infratentorial approach for infratentorial torcular meningioma is a safe and less invasive technique.
The D.C. nonprofit has entered into an MOU with Rambam Health Care to develop joint protocols for treating brain tumors in children and minimizing injuries from potential acts of terrorism
(University of Nottingham) Researchers at the University of Nottingham have discovered that repurposing a heart drug could significantly increase the survival rate for children with ependymoma - a type of brain tumour.
Gliomas including glioblastoma (GBM) are the most common primary malignant brain tumors. Glioma extracellular vesicles (EVs) including exosomes have biological effects (e.g. immunosuppression) and contain tumor-specific cargo that could facilitate liquid biopsies. We aimed to develop a simple, reproducible technique to isolate plasma exosomes in glioma patients. Glioma patients’ and normal donors’ plasma exosomes underwent brief centrifugation to remove cells/debris followed by serial density gradient ultracentrifugation (DGU). EV size/concentration was determined by nanoparticle tracking. Protein cargo was scr...
Conclusion: The risk signature with 5 genes could serve as an independent factor for predicting the prognosis of patients with GBM. Moreover, the nomogram with the risk signature and clinical traits proved to perform better for predicting 1, 3, 5-year survival rate.
Condition: Brain Tumor, Pediatric Intervention: Sponsor: Capital Medical University Recruiting
ConclusionsThe CNS penetration observed was encouraging enough to move ribociclib forward with preclinical efficacy studies in models of pediatric brain tumors.
Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.
CONCLUSIONS: The combination of different intraoperative imaging modalities may increase brain tumor safety and extent of resection. In particular, i-US seems to be highly sensitive to detect residual tumors, but it may generate false positives due to artifacts. Conversely, i-CT is more specific to localize remnants, allowing a more reliable updating of navigation data. PMID: 31298506 [PubMed - as supplied by publisher]
Conclusion: DTI fiber tracking based neuronavigation has merit in assessing the relation between lesions and adjacent white matter tracts, allowing prediction of patient outcomes based on lesion-CST distance. It has also proven beneficial in formulating surgical strategies. PMID: 31295976 [PubMed - as supplied by publisher]
CONCLUSIONS: Unbiased metabolic profiling of AT/RT identified susceptibility of high MYC AT/RT to glutamine metabolic inhibition with DON therapy. DON inhibited glutamine-dependent synthesis of glutathione and synergized with carboplatin to extend survival in high MYC AT/RT. These findings can rapidly translate into new clinical trials to improve survival in high MYC AT/RT. PMID: 31300448 [PubMed - as supplied by publisher]