Host Genetics, Innate Immune Responses, and Cellular Death Pathways in Poliomyelitis Patients

Conclusions: We suggest that genetic variants in innate immune defences and cell death pathways contribute to the clinical presentation of PV infection. Importantly, this study is the first to uncover the genetic profile in patients with PPM, combined with investigations of immune responses and viral burden in primary cells.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

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By MIKE STOBBE NEW YORK (AP) — This year has seen a record number of cases of a mysterious paralyzing illness in children, U.S. health officials said Monday.It's still not clear what's causing the kids to lose the ability to move their face, neck, back, arms or legs. The symptoms tend to occur about a week after the children had a fever and respiratory illness.No one has died from the rare disease this year, but it was blamed for one death last year and it may have caused others in the past.What's more, Centers for Disease Control and Prevention officials say many children have lasting paralysis. And close to half th...
Source: JEMS Operations - Category: Emergency Medicine Authors: Tags: Operations News Source Type: news
It is a scary illness, not just for parents but for doctors, too: Acute flaccid myelitis (AFM) causes sudden weakness and loss of muscle tone in the arms and legs and can go on to cause even more serious problems. It’s not just the symptoms that are scary. It’s also scary because we don’t know what causes it. Although the symptoms are similar to polio, patients with AFM have tested negative for polio. At one point it was thought that it was caused by another enterovirus, but that didn’t end up being the explanation. It may be another virus, or it may be some sort of toxin, or something else entirely...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Children's Health Neurological conditions Parenting Source Type: blogs
Acute flaccid myelitis, which has polio-like symptoms, can affect the spinal cord and can cause partial paralysis.
Source: ABC News: Health - Category: Consumer Health News Tags: WNT Source Type: news
Two children in Chicago are among the 38 children with a rare disease known as acute flaccid myelitis (AFM). One of them is two-year-old Julia Payne, who has been in the hospital for several weeks.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The Centers for Disease Control and Prevention (CDC) has so far this year recorded 127 suspected cases of a polio-like nervous system disorder that can cause paralysis, fueling an ongoing investigation into an outbreak of the rare disease. Of those 127 illnesses, 62 cases in 22 states are confirmed to be acute flaccid myelitis (AFM), the CDC said Tuesday. The CDC recorded only 33 confirmed cases of the severe condition — which typically affects kids and can result in muscle weakness or paralysis, respiratory failure and even death — during all of last year, though there were 149 cases the year before. “W...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Minnesota onetime Source Type: news
Three more children have come down with a polio-like nervous system disorder that can cause paralysis, fueling an ongoing investigation into an outbreak of the rare disease. Three children are being treated for suspected cases of acute flaccid myelitis (AFM) at UPMC Children’s Hospital of Pittsburgh, ABC News reports. The new patients join a cluster of cases in Minnesota and another in Colorado. As of September 30, the Centers for Disease Control and Prevention (CDC) had this year recorded 38 confirmed cases of the severe condition, which typically affects kids and can result in muscle weakness or paralysis, respirat...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Minnesota onetime Source Type: news
ConclusionrTMS can be an effective method in treatment of post polio syndrome but further studies with larger group need to be done to confirm that data.
Source: Polish Journal of Neurology and Neurosurgery - Category: Neurosurgery Source Type: research
Six-year-old who died was among nine children exhibiting symptoms consistent with AFM, a rare disease with no known cause or cure
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
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