N-chlorotaurine Inactivates Acanthamoeba and Candida albicans in the Porcine Ex Vivo Corneal Infection Model

Conclusions: NCT inactivates A. castellanii and C. albicans in corneal tissue.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research

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CONCLUSIONS: The use of orthodontic appliances alters the status of the oral cavity; it has impact on the colonization of oral biofilm by opportunistic/pathogenic strains, and increases the risk of their dissemination to various human tissues and organs. Pretreatment examination of oral microbiome, its monitoring particularly during treatment with fixed appliances, and preventive elimination of the potentially pathogenic strains to avoid health complications, are highly recommended, especially in patients with impaired immunity. PMID: 31232051 [PubMed - in process]
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Tags: Ann Agric Environ Med Source Type: research
Abstract: With the increasing incidence of more pathogens that can cause microbial keratitis (MK), it is necessary to periodically reassess disinfection multipurpose solutions testing requirements to ensure that relevant organisms to challenge them are being used. Current testing protocols have included common pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus, Serratia marcescens, Candida albicans, and Fusarium solani but have omitted less common pathogens such as Acanthamoeba. Specifically, Acanthamoeba sp. has recently been identified as a prevalent cause of MK in certain countries. Developing an appropri...
Source: Eye and Contact Lens: Science and Clinical Practice - Category: Opthalmology Tags: Review Article Source Type: research
ConclusionsRoutine investigations for co-infection and biofilm formation in addition to Acanthamoeba culture are strongly recommended in suspected AK cases. Co-infection with biofilm producers may precipitate extrinsic in-vivo drug resistance despite of the in-vitro sensitivity. Designing a biofilm-dissolving topical drug is highly recommended to enhance the response to the standard therapeutic regimen especially in the resistant AK cases.Graphical abstract
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: Available online 18 December 2016 Source:Microbial Pathogenesis Author(s): Sahreena Lakhundi, Ruqaiyyah Siddiqui, Naveed Ahmed Khan Microbial keratitis is a sight-threatening ocular infection caused by bacteria, fungi, and protist pathogens. Epithelial defects and injuries are key predisposing factors making the eye susceptible to corneal pathogens. Among bacterial pathogens, the most common agents responsible for keratitis include Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumonia and Serratia species. Fungal agents of corneal infections include both filamentous as well as yeast, inc...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionsDue to the percentage of positive results in the cultures of contact lenses is higher than the percentage of corneal scrapings its realization is useful, beacuse the microorganism isolated in the ulcer is also present in maintenance fluids. Due to the high sensitivity of the main microorganisms to quinolones, are recommended as initial empiric therapy in infectious keratitis.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research
CONCLUSIONS: This study has demonstrated that the CAP technology is highly effective against bacterial, fungal and protozoan pathogens. The further development of this technology has enormous potential as this approach is able to deliver the complete inactivation of ocular pathogens in minutes compared to commercial multipurpose disinfecting solutions which require a minimum 6 hrs. IMPORTANCE: This study has demonstrated that the CAP technology is highly effective against bacterial, fungal and protozoan pathogens. The further development of this technology has enormous potential as this approach is able to deliver the...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Tags: Appl Environ Microbiol Source Type: research
This study investigated and described the effect of the visible light on five different microorganisms. The studied groups were composed by the species Acanthamoeba polyphaga, Candida albicans, Mycobacterium massiliense, Pseudomonas aeruginosa, and Staphylococcus aureus. These microorganisms were analyzed after six light doses exposition with three different wavelengths: 450, 520, and 630 nm. The present study indicates two different behaviors: bioinhibition and/or biostimulation. The bioinhibition effect was calculated using different percentages of the microorganism population, compared to the control group, in whic...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
Conclusions: Our results, although preliminary, indicate that autofluorescence spectroscopy shows promise as a diagnostic technique for keratitis. We intend to expand the set of pathogens studied before assessing the feasibility of the technique in vivo by introducing cultures onto pig corneas.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research
The above article, published online on 30 June 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor in Chief, David Graham, and John Wiley &Sons Ltd. The retraction has been agreed due to the inclusion of plagiarised content from “Vacuoles of Candida yeast as a specialized niche for Helicobacter pylori”, World J Gastroenterol. 2014 May 14; 20(18): 5263–5273. doi: 10.3748/wjg.v20.i18.5263. The corresponding author, N Alipour, has taken responsibility for the manuscript and the unacknowledged overlap of which the other authors named on the pap...
Source: Helicobacter - Category: Gastroenterology Authors: Tags: THIS ARTICLE HAS BEEN RETRACTED Source Type: research
ConclusionH.pylori are therefore well equipped to establish in the vacuoles of Acanthamoeba, which provide them with essential nutrients for multiplication, as a pre‐adaptation for invasion of human cells. Due to general tropism of all bacteria to yeast extract, entrance of H. pylori into candida was modified by our experiments and it is corrected to “Acanthamoeba”.
Source: Helicobacter - Category: Gastroenterology Authors: Tags: Review Article Source Type: research
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