Changes in Corneal Wound Healing and Graft Biomechanics After Primary Penetrating Keratoplasty Versus Repeat Penetrating Keratoplasty
Purpose: To evaluate and compare the influence of the wound healing process at the graft edge on corneal biomechanics after primary penetrating keratoplasty (PK) and repeat PK. Methods: This retrospective comparative study included 95 eyes: 35 eyes of 35 patients had PK, 40 eyes of 40 patients underwent repeat PK, and 20 eyes of 20 normal subjects served as the control group. The ocular response analyzer was used to measure and compare corneal hysteresis and corneal resistance factor among the study groups at least 6 months after all sutures were removed. In vivo confocal microscopy was used to study the corneal wound healing process at the graft edge in PK and repeat PK groups and to correlate these findings with corneal biomechanics. Results: Corneal hysteresis and corneal resistance factor were significantly lower in the PK group (6.71 ± 1.3 and 5.99 ± 1.2 mm Hg, respectively) as compared with the repeat PK group (9.4 ± 1.03 and 8.77 ± 1.1 mm Hg, respectively) (P
ConclusionsThe study reveals a dynamic development of the eye bank over the last 30 years and emphasizes the importance of an active quality management in coping with the challenges of modern eye banking. The increasing trend of cornea collection and transplantation is a reflection of the needs and efforts towards treating and eliminating corneal blindness.
Conclusions: Although there are significantly fewer amounts of peripheral cells available after graft preparation for keratoplasty, these cells can still be used for endothelial cell culture due to their proliferative capability. The peripheral cells that are discarded after graft preparation can thus be utilized to increase the donor endothelial cell pool for regenerative treatments. PMID: 31428467 [PubMed]
We read with great interest the article “Effect of keratoconus severity on clinical outcomes after deep anterior lamellar keratoplasty” by Feizi and associates.1 The authors have brought out clarity on an essential aspect of keratoplasty in keratoconus, that is, the impact of clinical severity on the outcomes of deep anterior lamellar keratoplasty (DALK). However, there are a few concerns that we would like to highlight.
Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear. We addressed this important question in a mouse model of ocular HSV-1 infection, where sensory nerve damage is a common clinical problem. Through genetic and pharmacologic targeting, we uncovered a central role for C3 in sensory nerve damage at the morphological and functional levels. Interestingly, CD4 T cells were central in facilitating this complement-mediated damage. This same C3/CD4 T cell axis triggered corneal sensory nerve damage in a mouse model of ocular gra...
Conditions: Fuchs' Endothelial Dystrophy; Cataract Intervention: Drug: Netarsudil 0.02% Ophthalmic Solution Sponsor: Massachusetts Eye and Ear Infirmary Recruiting
Condition: Fungal Keratitis Intervention: Device: Lamellar keratoplasty-ABCcolla® Collagen Ophthalmic Matrix Sponsor: ACRO Biomedical Co. Ltd Recruiting