Tumour response in non ‐small‐cell lung cancer patients treated with chemoradiotherapy – Can spectral CT predict recurrence?

AbstractIntroductionTumour response in lung cancer treatment is monitored by measuring lesion size in computed tomography (CT). Spectral CT (SCT) offers additional information on tumour tissue besides morphology. We evaluated SCT iodine content (IC) and performed spectral slope analysis to assess the response of non ‐small‐cell lung cancer (NSCLC) to chemoradiotherapy (CRT).MethodsEighty ‐three patients with advanced NSCLC treated by CRT prospectively underwent single‐phase, contrast‐enhanced SCT. Evaluation of all patients included treatment response (RECIST 1.1), quantitative measurements as well as SCT IC determination and spectral slope analysis in NSCLC primaries. Measure ments were performed at the maximum cross‐diameter of tumours and in areas with high iodine values (hotspot analysis). Iodine difference (ΔIC) was calculated. Secondary outcome parameters were IC and spectral slopes in mediastinal lymph nodes (n = 61).ResultsTwenty ‐four patients (29%) showed complete remission after CRT. Thirty‐four patients (41%) had stable disease (SDSCT) or partial regression (PRSCT). Progressive disease (PDSCT) was seen in 25 patients (30%). Hotspot analysis showed significantly higher iodine values in PDSCT than in SDSCT/PRSCT (P 
Source: Journal of Medical Imaging and Radiation Oncology - Category: Radiology Authors: Tags: Medical Imaging —Radiation Oncology—Original Article Source Type: research

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AbstractObjectiveMetabolic tumor volume (MTV) and total lesion glycolysis (TLG) are imaging parameters derived from 18F-FDG PET/CT that have been proposed for risk stratification of cancer patients. The aim of our study was to test whether these whole-body volumetric imaging parameters may predict outcome in patients with non-small cell lung cancer (NSCLC).MethodsSixty-five patients (45 men, 20 women; mean age  ± SD, 65 ± 12 years), with histologically proven NSCLC who had undergone 18F-FDG PET/CT scan before any therapy, were included in the study. Imaging parameters includin...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
AbstractPositron emission tomography and computed tomography (PET –CT) is the non-invasive gold standard method for determining the oncological stage of patient with diagnosis of lung cancer. A correct preoperative staging is significant because only patients who do not have a history of regional or distant disease are those who will benefit from a surgical trea tment. However, due to the different values of the PET–CT in terms of sensitivity and specificity to evaluate the mediastinal lymph node involvement, it is often necessary to perform a surgical mediastinal sampling through a cervical video mediastinosco...
Source: Updates in Surgery - Category: Surgery Source Type: research
Abstract PURPOSE: Elderly patients with multiple primary or oligometastases (
Source: Journal of Applied Clinical Medical Physics - Category: Physics Authors: Tags: J Appl Clin Med Phys Source Type: research
In a patient who had been diagnosed of located squamous cell lung carcinoma, pneumonectomy and adjuvant chemotherapy were performed. Brain recurrence and subsequent lung metastatic disease were uncontrolled by neurosurgery, holocranial radiotherapy and first-line chemotherapy. In August 2015, appearance of leptomeningeal carcinomatosis triggered severe clinical deterioration and threatened the patient's life. Anti-PD1 immune checkpoint inhibitor Nivolumab was initiated in an attempt to stop tumour growth, achieving a spectacular brain and pulmonary complete response and clinical improvement, without serious adverse effects...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
The authors regret they failed to note that the treatment period for patients included in this report occurred between 2000 and 2010 and not through the stated 2015 end date. The findings described, then, do not represent final data (including total numbers of patients and results) or conclusions for patients treated after 2010. Complete study data remain at the University of Maryland School of Medicine.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Corrigendum Source Type: research
Conclusion: This first-in-human study demonstrates that 99mTc-labeled anti–PD-L1-single-domain antibody SPECT/CT imaging is safe and associated with acceptable dosimetry. Tumor uptake is readily visible against background tissues, particularly at 2 h when the T:BP ratio correlates with PD-L1 immunohistochemistry results.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
Publication date: Available online 31 August 2019Source: The Annals of Thoracic SurgeryAuthor(s): Eric M. Robinson, Ilkka K. Ilonen, Kay See Tan, Andrew J. Plodkowski, Matthew Bott, Manjit S. Bains, Prasad S. Adusumilli, Bernard J. Park, Valerie W. Rusch, David R. Jones, James HuangABSTRACTBackgroundThere has been growing interest in limited resection and nonsurgical treatment for small lung cancers. Our objective was to examine the pattern and rate of occult N1 nodal metastasis in patients with peripheral, small (≤2 cm), clinically node-negative non-small cell lung cancer (NSCLC).MethodsPatients with peripheral
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS: This study reveals the associations between CT imaging radiomics features and NSCLC co-expressed gene sets. The findings suggest that CT radiomics features can reflect important biological information of NSCLC patients, which may have a significant clinical impact as CT is routinely used in clinical practice, assisting in improving medical decision-support at low cost. PMID: 31450540 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - Category: Radiology Tags: J Xray Sci Technol Source Type: research
AbstractPurposeThe high rates of failure in the radiotherapy target volume suggest that patients with stage II or III non-small-cell lung cancer (NSCLC) should receive an increased total dose of radiotherapy. 2-Deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) and [18F]fluoromisonidazole ([18F]FMISO) (hypoxia) uptake on pre-radiotherapy positron emission tomography (PET)/X-ray computed tomography (CT) have been independently reported to identify intratumor subvolumes at higher risk of relapse after radiotherapy. We have compared the [18F]FDG and [18F]FMISO volumes defined by PET/CT in NSCLC patients included in a prospective study....
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
This study aimed to determine the preoperative risk factors for pN2 disease, as well as its incidence and long-term outcomes, in patients with clinical N0-1 non-small cell lung cancer. Methods: We retrospectively analyzed patients who were treated surgically for primary non-small cell lung cancer from November 2005 to December 2014. Patients staged as clinical N0-1 via chest computed tomography (CT) and positron emission tomography (PET)-CT were divided into two groups (pN0-1 and pN2) and compared. Results: In a univariate analysis, the significant preoperative risk factors for pN2 included a large tumor size (p=0....
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
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