New bipolar depression treatment misses the mark in recent study

A new treatment being investigated for bipolar depression has failed to meet its main goal in a recent study.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news

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Authors: Yatham LN, Vieta E, McIntyre RS, Jain R, Patel M, Earley W Abstract Introduction: Bipolar disorder is a complex mood disorder characterized by a chronic and subtle course of fluctuating manic/hypomanic and depressive symptoms. Cariprazine, a dopamine D₃-preferring D₃/D₂ receptor partial agonist with serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. Post hoc analyses evaluated efficacy across symptoms in bipolar depression. Methods: Pooled data were analyzed from 3 phase 2 or 3, randomized, ...
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Conclusions: There was wide variation in suggestions on to how to treat persistent symptoms of anxiety, ADHD, and oppositional behavior in a child whose mania and depression had been brought under good control. We surmise that this great diversity in recommendations among experts in child and adult bipolar disorder stems at least partially from inadequate literature on treatment and that a new emphasis on funding and conducting studies on efficacy and effectiveness is needed. PMID: 32942345 [PubMed - as supplied by publisher]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders. World Psychiatry. 2020 Oct;19(3):360-380 Authors: Firth J, Solmi M, Wootton RE, Vancampfort D, Schuch FB, Hoare E, Gilbody S, Torous J, Teasdale SB, Jackson SE, Smith L, Eaton M, Jacka FN, Veronese N, Marx W, Ashdown-Franks G, Siskind D, Sarris J, Rosenbaum S, Carvalho AF, Stubbs B Abstract There is increasing academic and clinical interest in how "lifestyle factors" traditionally associated with physical health may also relate to mental health...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
Abstract Emil Kraepelin developed a new psychiatric nosology in the eight editions of his textbook. Previous papers have explored his construction of particular diagnoses, including dementia praecox and manic-depressive insanity. Here we are providing a close reading of his introductory textbook chapter, that presents his general principles of nosology. We identify three phases: 1) editions 1-4, in which he describes nosological principles in search of data; 2) editions 5-7, in which he declares the mature version of his nosological principles and develops new disease categories; 3) edition 8, in which he qualifie...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
Authors: Brogan K, Jarvi A, Klopf H, Turner T Abstract Background: This case report illustrates that the use of a series of lifestyle interventions delivered via the "Vital Mind Reset" online program led to the resolution of disabling psychiatric symptoms. Summary: A 40-year-old, married, Caucasian female, with onset of suicidal ideation as a teenager, was treated with antidepressants and was later formally diagnosed with dissociative identity disorder (DID), borderline personality traits, and bipolar disorder (BD). In the ensuing years, the patient was treated with 35 psychiatric medications. Additio...
Source: Advances in Mind Body Medicine - Category: Psychiatry Tags: Adv Mind Body Med Source Type: research
ConclusionsAlthough results must be interpreted with caution because of the small sample, this preliminary study suggests that depressed bipolar and schizoaffective patients share common biological dysregulations, distinct from that of paranoid schizophrenic patients. From a pathophysiological viewpoint, paranoid schizophrenic patients can be characterized by hyposensitivity of the hypothalamic DA receptors (possibly resulting from an increase in presynaptic DA release) associated with increased HPA axis activity, while depressed bipolar and schizoaffective patients can be characterized by hyposensitivity of the pituitary ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Today is National Physician Suicide Awareness Day. To honor this day, we could discuss the statistics of how 300-400 physicians die each year due to suicide. But, instead, this is the story of Dr. Justin Bullock, a resident physician with Bipolar Disorder. A narrative of survival.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation Source Type: news
Can people with schizophrenia fall in love? Can they date or even get married? In today’s episode, host Rachel Star Withers (a woman who lives with schizophrenia) and co-host Gabe Howard review their own past romantic experiences. They also interview Andrew and Stephanie Downing, authors of Marriage and Schizophrenia: Eyes on the Prize. Listen to learn about their incredible journey of overcoming schizophrenia and building a healthy, rewarding, and happy marriage. Computer Generated Transcript of “Love, Dating, Marriage with Schizophrenia” Episode Editor’s Note: Please be mindful that this trans...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Marriage and Divorce Motivation and Inspiration Podcast Relationships Sexuality Source Type: blogs
BACKGROUND: Prevention of suicide in individuals with early-onset bipolar disorder (BD) remains a challenge. Diffusion magnetic resonance imaging studies in BD have identified neural correlates of emotional dysregulation implicated in BD and suicide. Using...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Around 1-2% of the population live with bipolar disorder (BD) [1]. Although women and men experience bipolar disorder at similar rates, there may be some differences between men and women in how they experience clinical features of the illness [2, 3]. Depressive symptoms have also been found to be more prominent for women [2], and women also report higher rates of family suicide and attempted suicides [4]. In some studies women have been reported to experience more rapid mood cycling, (experiencing four or more episodes of depression or mania within the one year) than men [3] and to be more vulnerable to sleep loss as a tr...
Source: Maturitas - Category: Primary Care Authors: Source Type: research
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