New bipolar depression treatment misses the mark in recent study

A new treatment being investigated for bipolar depression has failed to meet its main goal in a recent study.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news

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Authors: Theodoropoulou S, Gialouris AG Abstract Brain is an organ with the highest lipid concentration in the body. Cellular membrane lipids can affect both the positioning and the functioning of membrane proteins, thus regulating several cell actions. Changes in the lipid composition of cell membrane can modulate the microenvironment and consequently the function of its proteins, e.g. neurotransmission. Some of the first studies on the subject have shown a negative correlation between serum cholesterol levels and depression, suicidality and behavioral disorders. Several studies -but not all- have found decreased ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
  Schizophrenia does not just affect the person with schizophrenia, but their families, also. This episode of Inside Schizophrenia explores the family relationships impacted by schizophrenia, both immediate and extended.  Two guests join us. The first is Chrisa Hickey, who is the mother of an adult son with schizophrenia and started an online site for parents of children who have a severe mental illness. The other guest, interviewed by co-host Gabe Howard, is Janel Star Withers, mother of host Rachel Star Withers. Janel shares her experiences with raising a schizophrenic daughter.  Host Rachel Star Withers, ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Children and Teens Family General Inside Schizophrenia Mental Health and Wellness Parenting Bipolar disorder and schizophrenia Family Mental Health family mental illness Helping Families in Mental Health Crisis life with schizophrenia Source Type: blogs
Pharmacopsychiatry DOI: 10.1055/a-0991-0582The treatment of depressive episodes remains complicated by the long latency of antidepressant efficacy, insufficient response, and high risk of suicide. Ketamine and esketamine have been proposed as fast-acting substances able to overcome these impediments.Since the first randomized controlled trial in the year 2000, numerous studies have explored the antidepressant efficacy of ketamine and esketamine. Clear evidence has emerged that a single infusion exerts a significant antidepressant and antisuicidal effect in both unipolar and bipolar depression. A few studies suggest that an...
Source: Pharmacopsychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research
TUESDAY, Aug. 20, 2019 -- Environmental pollution appears to be associated with an increased risk for psychiatric disorders, especially bipolar disorder and major depression, according to a report published online Aug. 20 in PLOS Biology. Atif Khan,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
In this study, we applied parallel independent component analysis (pICA) to structural neuroimaging measures and the positive and negative syndrome scale (PANSS) in 110 patients (mean age 34.9 ± 11.65) with bipolar disorder, to examine networks of brain regions that relate to symptom profiles. The pICA revealed two distinct symptom profiles and associated GM concentration alteration circuits. The first PANSS pICA profile mainly involved anxiety, depression and guilty feelings, reflecting mood symptoms. Reduced GM concentration in right temporal regions predicted worse mood symptoms in this profile. The second PA...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
BACKGROUND: Studies aimed at understanding the higher risk profiles for self-inflicted violence in individuals with BD become essential as a possible predictive risk measure for the presence of suicidal behavior, corroborating the expressive reduction of s...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
CONCLUSIONS: Considering the fact that LAIs are highly underused in patients with severe mental disorders and there is lack of awareness about LAIs among patients with severe mental disorders, the present study findings suggest that there is reasonable level of acceptance of LAIs among patients with severe mental disorders when explained about the same. PMID: 31419737 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
The first reason flows from the following release for the Federal Health Department.Building a Mentally and Physically Healthy AustraliaDelivering the world ’s best mental health system – stigma-free and focused on prevention, starting with children under 12 – is the major focus of the Australian Government’s Long Term National Health Plan, outlined today. Date published: 14 August 2019Delivering the world ’s best mental health system – stigma-free and focused on prevention, starting with children under 12 – is the major focus of the Australian Government’s Long Term Nat...
Source: Australian Health Information Technology - Category: Information Technology Authors: Source Type: blogs
CONCLUSIONS: In a large community-based sample in middle to early old age, bipolar disorder and depression were associated with lower visuospatial memory performance, in part potentially due to psychotropic medication use. Mood disorders and their treatments will have increasing importance for population cognitive health as the proportion of older adults continues to grow. DECLARATION OF INTEREST: I.J.D. is a UK Biobank participant. J.P.P. is a member of the UK Biobank Steering Committee. PMID: 31412972 [PubMed - as supplied by publisher]
Source: The British Journal of Psychiatry for Mental Science - Category: Psychiatry Tags: Br J Psychiatry Source Type: research
Conditions:   Depressive Disorder, Major;   Depression, Bipolar Intervention:   Device: Electroconvulsive therapy Sponsor:   Region Örebro County Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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