Zimbabwe: 500 People for New HIV Drug Trials

[The Herald] Zimbabwe has become the first country in the Sub-Saharan Africa region to complete the successful enrolment of participants who are taking part in the ongoing large-scale HIV vaccine efficacy trials which are currently underway on four continents, covering 12 countries with about 12 669 study participants on board.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news

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CONCLUSIONS: RC remains a frequent argument against the availability and provision of prevention methods for vulnerable populations. Individuals should be able to benefit from the full panel of BIs options available, to find and adapt methods according to their needs. Current, past and future PrEP users, with other stakeholders, may provide valuable insight into innovative solutions and programmes to control HIV and other STIs. PMID: 31468693 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
CONCLUSIONS: A tailored practice improvement plan can be envisioned to achieve an optimally functioning STI care continuum. PMID: 31468743 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
[New Times] Global experts are going to share research on HIV vaccines and cures in a meeting that will bring together over ten thousand delegates in Kigali in December.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
This article aims to present the hepatitis B (hepatitis B surface antigen - HBsAg) and C (anti-HCV) seroprevalence estimates and risk factors as per the 8th edition of the Conscript Survey performed in 2016. This cross-sectional study was conducted among conscripts across Brazil aged 17 to 22 years from August to December 2016. It included a self-reported questionnaire and blood testing for syphilis, human immunodeficiency virus (HIV), and hepatitis B and C. In total 38,247 conscripts were enrolled; after applying exclusion criteria, 37,282 conscripts were included. The estimated HBsAg and anti-HCV prevalence rates were ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
[Daily News] THE Muhimbili University of Health and Allied Sciences (MUHAS), has embarked on the third stage of HIV vaccine trials involving participants who are at high risk of contracting the disease.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
FINDINGSBased on a 2017 rate of vaccination against HPV among a group of California 20-year-olds, researchers estimate that this group is at risk for an excess of 1,352 cases of cancer that could be prevented with a 99.5% vaccination rate. Treatment for these preventable cancers would cost the health care system $52.2 million. The size of the group was 296,525 people, the approximate number of 20-year-olds in California in 2017.BACKGROUNDHuman papillomavirus, or HPV, is the most common sexually transmitted infection in the United States and is linked to seven types of cancer: cervical, vaginal, vulvar, penile, rectal, anal...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
[Cameroon Tribune] Under the patronage of the First Lady, the Governor of the Centre Region has launched the campaign to curb HIV/STIs in the Mefou and Akono Division.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
Discussion A preventative strategy aimed at protecting against HIV infection must block several steps during the earliest stages of infection, avoiding not only the productive infection of primary target cells, but also the viral dissemination toward distal tissues. In both scenarios, antigen-presenting cells residing in different compartments of the female genital mucosa may play a prominent role (7, 9, 24, 35). DC-T cell conjugates represent an optimal milieu for productive HIV infection, which may boost initial viral replication of CD4+ T cells (10, 36). Moreover, uninfected DCs could promote HIV dissemination to drain...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, our findings demonstrate that in the presence of an HIV-1 infection, the cellular distribution of FcγRIIIa is altered and that the functional consequence of FcγRIIIa variant is affected. Importantly, it underscores the need to characterize FcγR expression, cellular distribution and functional consequences of FcγR genetic variants within a specific environment or disease state. Introduction Receptors for the Fc domain of immunoglobulin G (IgG), so called Fc gamma receptors (FcγRs), link the specificity of IgG with potent effector functions of the innate immune system. Fc&ga...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions Apart West Nile virus (78), thousands of congenital microcephaly cases, fetal brain tissue damage and neurological syndromes have been associated with ZIKV infection. Unfortunately, the epidemics of this mosquito born, and a relative stable virus is on a rise. Although congenital microcephaly is a rare disorder however, due to lack of standardized diagnostic test facilities, the incidence in the geographically widespread ZIKV epidemic regions is higher. Animals studies showed that ZIKV is a neurotropic virus. It directly targets the developing embryonic brain cells by inducing apoptosis, cell-cycle arrest, and...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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