Autophagy inhibition potentiates ruxolitinib-induced apoptosis in JAK2 V617F cells

In conclusion, ruxolitinib induces autophagy in JAK2V617F cells, potentially by modulation of mTOR-, STAT- and BCL2-mediated signaling. This may lead to inhibition of apoptosis. Our results suggest that the combination of ruxolitinib with pharmacological inhibitors of autophagy, such as chloroquine, may be a promising strategy to treat patients with JAK2V617F-mutated MPNs.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research