Overexpression of TIPE2, a Negative Regulator of Innate and Adaptive Immunity, Attenuates Cognitive Deficits in APP/PS1 Mice
In this study, we compared the gene and protein expres sions of TIPE2 between the APP/PS1 mice and the age-matched wild type (WT) mice at different stages of development using western blot and RT-qPCR. The hippocampal expression of the TIPE2 mRNA and protein in APP/PS1 mice was higher than that of the WT mice starting from 6 months to 10 months. Howev er, the difference of the TIPE2 expression between the APP/PS1 mice and the WT mice declined in a time-dependent manner. The spatial learning and memory deficit from the 8-month-old APP/PS1 mice was observed in the Y-maze test and fear conditioning task. Interestingly, overexpression of TIPE2 by int ra-hippocampal injection of AAV-TIPE2 into APP/PS1 mice resulted in an improvement of learning and memory and reduced expression of inflammatory cytokines, such as TNF-α, IL-6 and IL-1β, and increased expression of anti-inflammatory cytokines, such as IL-10 and Arg-1. Taken together, our findings show that the TIPE2 expression level was negatively correlated with the pathogenesis of Alzheimer’s disease, and overexpression of TIPE2 attenuates cognitive deficits in APP/PS1 mice, suggesting TIPE2 is a potential target for pharmacological intervention and improvement of cognitive deficits.Graphical Abstract.
Publication date: 18 January 2020Source: New Scientist, Volume 245, Issue 3265Author(s): Alice Klein
DEMENTIA is a progressive neurological condition that mainly affects people over the of 65, although it is not a natural part of ageing. Spotting the early warning signs is key to maintaining quality of life for as long as possible. A recent study suggests that Alzheimer ’s disease, the most common form of dementia, can be signalled by a change in your eyes.
Authors: Herring WJ, Ceesay P, Snyder E, Bliwise D, Budd K, Hutzelmann J, Stevens J, Lines C, Michelson D Abstract INTRODUCTION: We evaluated the clinical profile of the orexin receptor antagonist suvorexant for treating insomnia in patients with mild-to-moderate probable Alzheimer's disease (AD) dementia. METHODS: Randomized, double-blind, 4-week trial of suvorexant 10 mg (could be increased to 20 mg based on clinical response) or placebo in patients who met clinical diagnostic criteria for both probable AD dementia and insomnia. Sleep was assessed by overnight polysomnography in a sleep laboratory. The primar...
Authors: Fossel M PMID: 31943780 [PubMed - as supplied by publisher]
The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once.
ConclusionThese results demonstrate that vortioxetine may improve cognitive impairment in 5 ×FAD mice. The role in cognitive improvement may be related to the beneficial effects of vortioxetine on synaptic function.
CONCLUSIONS: ¹⁸F-FC119S PET provides high sensitivity and specificity in detecting AD and therefore may be considered a useful diagnostic tool for AD. PMID: 31942769 [PubMed]
Publication date: Available online 17 January 2020Source: Life SciencesAuthor(s): Hongmei Wang, Ting Zhang, Xuhua Ge, Jingjiong Chen, Yuwu Zhao, Jianliang FuAbstractAimsMitochondrial dysfunction is an early prominent feature of Alzheimer's disease (AD). In the present study, we sought to investigate whether defective mitophagy is tightly related to amyloid-β (Aβ)-induced mitochondrial dysfunction.Main methodsImmunofluorescence, western blot and transmission electron microscopy were used to examine mitophagy. Mitochondrial membrane potential was assessed using the JC-1 dye. Mitochondrial ROS was detected using Mit...
Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC09233A, CommunicationGuanglei Lv, Anyang Sun, Minqi Wang, Peng Wei, Ruohan Li, Tao Yi Detection of A β protofibrils at the early stage of Alzheimer's disease was realized by a novel near-infrared probe (DCM-AN) based on dicyanomethylene-4H-pyran. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry