Radiation therapy-induced reactive oxygen species specifically eliminates CD19+  IgA+  B cells  in nasopharyngeal carcinoma

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

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Conclusion: The half-life clearance of plasma EBV DNA was prognostic in non-metastatic NPC staged and treated in the contemporary era. Earlier biomarker surveillance during treatment should be considered.Clinical Trial Registration: This study has been registered with ClinicalTrials.gov (Identifier: NCT03830996).
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Murakami N, Cheng G, Yoshimoto S, Itami J Abstract Nasopharyngeal cancer generally responds well to concurrent chemoradiotherapy (CCRT). However, there is a small group of patients who respond poorly to CCRT, and experience local residual tumor or local relapse. Although several attempts have been performed to such a group of patients including re-irradiation with external beam radiation therapy (EBRT) or salvage surgery, clinical results remain unsatisfactory. Intracavitary brachytherapy (ICBT) boost after CCRT with EBRT has been explored, however, its efficacy is limited to those with superficial residua...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Aman Sharma, Amit BahlJournal of Cancer Research and Therapeutics 2020 16(3):425-433 Head-and-neck cancer (HNC) is in close proximity to several critical structures. Intensity-modulated radiation therapy (IMRT) has the potential of generating highly conformal and concave dose distributions around complex target and is ideally suited for HNC treatment. Conventionally, the focus of IMRT for HNC patients has been on prevention of radiation-induced parotid dysfunction. In the present article, we review the potential of IMRT to reduce the risk of posttreatment aspiration and dysphagia and spare submandibular gland. We also dis...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Mi-Jo Lee, Hyun-Jin SonJournal of Cancer Research and Therapeutics 2020 16(3):653-656 Nasopharyngeal sarcomatoid carcinoma (SaCa) is extremely rare, and concurrent chemoradiation is the standard treatment for squamous cell-based nasopharyngeal cancer (NPC). This case report gives the first explanation of a nasopharyngeal SaCa patient treated with volumetric modulated arc therapy (VMAT) with simultaneous integrated boost (SIB), which is an excellent treatment modality that leads to complete response for locally advanced NPC. A 70-year-old male presented with nasal obstruction, epistaxis, and right neck node enlargements. E...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
Nasopharyngeal carcinoma (NPC) is the most common head and neck cancer in southern China. Radiotherapy is the primary therapeutic approach for NPC, rather than surgery. With the wide application of intensity-modulated radiation therapy (IMRT), better treatment outcomes of NPC patients were achieved in modern era. But distant metastasis and local-regional relapse are still the causes of treatment failure, especially the former [1 –4]. Screening NPC patients with a high risk of distant metastases and local-regional relapse has implications for making informed decisions about NPC treatment.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
Our study shows the distribution patterns and prognoses of distant metastases among 4 histological types in NPC. A nomogram was constructed for clinical use based on 4 independent prognostic risk indicators, including histology, radiation therapy, chemotherapy and metastatic status. Our findings provide a reference for clinical decision ‐making and future diagnostic screening tests for NPC with distant metastases. AbstractCurrently, the features and prognosis of nasopharyngeal carcinoma (NPC) with distant metastases are still rarely reported. Thus, the main purpose of our study was to investigate the metastasis patterns ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
OBJECTIVE: To analyze the pattern of local failure in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT) and find a more reasonable delineation of the clinical target volume (CTV).METHODS AND MATERIALS: A total of 212 patients with non-metastatic NPC who underwent IMRT were analyzed. Radiation therapy was run at a total dose of 66-74 Gy (2.0-2.2 Gy fractions). The follow-up of local recurrence and the recurrence-related features were analyzed for the original treatment situation. The failures were delimited as “in-field failure” if Vrecur within the 95% isodose curve (V95...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck in Southeast Asia and southern China. Although the comprehensive treatment based on intensity-modulated radiation therapy improves outcomes, the five-year survival rate of NPC patients is low, and the recurrence remains high. Radiotherapy resistance is the main cause of poor prognosis in NPC patients. MicroRNAs (miRNAs) are a class of endogenous non-coding RNAs regulating various biological functions in eukaryotes. These miRNAs can regulate the development and progression of nasopharyngeal carcinoma by affecting the proliferation...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Nasopharyngeal carcinoma (NPC), also known as the “Canton tumor”, is one of the most common cancers in southern China. In Hong Kong, the Hong Kong Cancer Registry has noted that NPC was the 6th most common cancer in males with 599 new cases and an incidence rate of 17.7 in 100,000 in 2016. The mortality of NPC ranked 8th in male and 10th in bot h sexes [1]. The first-line treatment for nasopharyngeal cancer is radiation therapy. Xerostomia is a common, debilitating complication of radiation therapy for nasopharyngeal carcinoma [2].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Our study revealed the change of saliva electrolytes and xerostomia-related quality of life in patients undergone IMRT for NPC. PMID: 32544605 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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