Deficiency of Epithelial –Mesenchymal Transition Causes Child Indirect Inguinal Hernia

Epithelial –mesenchymal transition (EMT) describes rapid changes in cellular phenotype. During EMT, epithelial cells down-modulate cell–cell adhesion, alter polarity, reorganize cytoskeleton, become isolated, motile, and resistant to anoikis. Epithelial breakdown and epithelial cell migration are the key p rocesses involved in the obliteration of processus vaginalis. The great majority of abnormalities are because of nonobliteration or incomplete fusion of PV. We aimed to analyze the quantitative changes of epithelial genes in adult/child patients and their controls to examine differences of the genes is of these hernias.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research

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You're reading Testicular pain: Everything you need to know as a parent, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Does your of age son often complain about the pain in testicles? Does he feel uncomfortable while riding his bicycles or bike? If yes! It could be testicular pain which mostly occurs among teenage boys.  It’s very uncommon to see the pain in boys above 25 years old. Testicular pain often requires immediate medical attention. If the treatment is started within 6 hrs of beginning of the pain, ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Causes of Testicular Pain in Children Kidshealth Testicle Pain Testicle Pain in Children Testicular Pain in Kids Source Type: blogs
AbstractPurposeWe compared the outcomes of laparoscopic surgery (LS) with those of open surgery (OS) for unilateral and bilateral pediatric inguinal hernia.MethodsUsing a nationwide claim-based database in Japan, we analyzed data from children younger than 15  years old, who underwent inguinal hernia repair between January 2005 and December 2017. Patient characteristics, incidence of reoperation, postoperative complications, length of hospital stay, and duration of anesthesia were compared between LS and OS for unilateral and bilateral hernia.ResultsAmong 5554 patients, 2057 underwent LS (unilateral 1095, bilateral 96...
Source: Surgery Today - Category: Surgery Source Type: research
Publication date: 13–19 July 2019Source: The Lancet, Volume 394, Issue 10193Author(s): Ankoor Talwar, Abhinav Talwar, Arunabh Talwar
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionGiant inguinoscrotal hernias should be defined and evaluated as a group apart from classical inguinoscrotal hernias. Recurrence and morbidity rates were lower in patients who underwent hernioplasty using Zig maneuver.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
ConclusionHigh index of clinical suspicion and early intervention saves the patient from extensive bowel resection and other serious complications.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
The male genital examination is a common source of discomfort for the patient and medical provider. Performance of male genital examination is imperative; however, as many treatable diagnoses can be made. Undescended testicles (UDTs), hernias, testicular tumors, and urethral abnormalities are all potentially concerning findings which can be discovered on routine examination.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research
Mucopolysaccharidosis (MPS) I is an autosomal recessive lysosomal storage disorder resulting from a deficiency in the lysosomal enzyme α-l-iduronidase, leading to the accumulation of the glycosaminoglycans (GAGs) dermatan sulfate (DS) and heparan sulfate (HS) in cells throughout the body. The clinical characteristics of MPS I include cognitive impairment (severe form), coarse facial features, corneal clouding, respiratory disorder s, cardiac diseases, hepatomegaly, umbilical and inguinal hernias, skeletal abnormalities, and joint contractures.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Short Communication Source Type: research
Conclusions: All patients had successful abdominal wall closure. Most of the patients had minimal scar of the large hernia repair and the umbilicus was normal looking and well accepted cosmetically.
Source: Journal of Indian Association of Pediatric Surgeons - Category: Surgery Authors: Source Type: research
ConclusionThis preliminary study showed that NAIRS after cauterization of the neck of the hernia sac in infants and children is safe, feasible, reproducible with excellent cosmetic results.
Source: Hernia - Category: Sports Medicine Source Type: research
ConclusionThis study suggests that fewer 0 –4-year olds are undergoing inguinal herniotomy, compared with 20 years ago. This is likely due to a change in practice for the management of unilateral symptomatic hernias, from routine bilateral herniotomies, to unilateral surgery. As well as less aggressive surgical intervention for hydroceles in boys.Level of evidenceIII.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
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