Deficiency of Epithelial –Mesenchymal Transition Causes Child Indirect Inguinal Hernia

Epithelial –mesenchymal transition (EMT) describes rapid changes in cellular phenotype. During EMT, epithelial cells down-modulate cell–cell adhesion, alter polarity, reorganize cytoskeleton, become isolated, motile, and resistant to anoikis. Epithelial breakdown and epithelial cell migration are the key p rocesses involved in the obliteration of processus vaginalis. The great majority of abnormalities are because of nonobliteration or incomplete fusion of PV. We aimed to analyze the quantitative changes of epithelial genes in adult/child patients and their controls to examine differences of the genes is of these hernias.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research