Transcriptome analysis of FEN1 knockdown HEK293T cell strain reveals alteration in nucleic acid metabolism, virus infection, cell morphogenesis and cancer development.

CONCLUSION: These findings provide insight into how FEN1 nuclease might regulate a wide variety of biological processes, and laid the foundation for understanding the role other RAD2 family nucleases in cell growth and metabolism. PMID: 31272350 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31272350?dopt=Abstract

Source: Combinatorial Chemistry and High Throughput Screening - July 2, 2019 Category: Chemistry Authors: Liu SB, Qiu XQ, Guo WQ, Li JL, Su Q, Du JH, Hu HJ, Wang XX, Song YH, Lou X, Xu XB Tags: Comb Chem High Throughput Screen Source Type: research