Effect of Training with or without Ziziphus Jujuba Extract on Cardiokines in Heart Tissue of Myocardial Infarcted Rats
Background:Today, the importance of physical activity as a preventative way for cardiovascular disease has attracted much attention.The aim of this study is to investigate the effect of 6 weeks of interval training with or without extract of Ziziphus jujuba on lipocalcin ‑2 (LCN2) and adiponectin levels in heart tissue in male Wistar rats with myocardial infarction.Methods:Thirty male Wistar rats (mean weight, 180 –220 g and age, 2–3 months) were divided into fve groups, including (1) Healthy control; (2) Isoprenaline‑treated group (ISO); (3) ISO + jujube extracts (JE); (4) Trained ISO rats; and (5) Trained ISO rats + JE. Exercise was performed (5 days/week, for 6 week including 54‑min cycles with spe ed of 23 m/min and 54‑min cycles with speed of 15 m/min). After 48 h of the last training session, the rats were sacrifced, and their heart tissue was excised. The signifcant level of statistical data was analyzed by one‑way ANOVAtest.Results:LCN2 levels signifcantly decreased in trained ISO rats + JE group after 6 weeks of interval training with JE consumption, compared to ISO group. However, the consumption of jujuba extracts with and without interval training did not show any signifcant changes in adiponectin levels of rat ’s heart tissue, compared to ISO(P
ConclusionThe findings from this study have established the need to improve current education and rehabilitation programmes for patients with CHF by addressing those factors significantly influencing their adherence to diet and medication.
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SUNDAY, Nov. 17, 2019 -- A cheap drug that's been around for centuries as a gout treatment might also shield heart attack survivors from future heart crises, new trial results show. The drug, colchicine, is derived from a plant called the autumn...
A new study from South Korea finds that increased activity can reduce the risks of heart attack and stroke among people over the age of 60.
For patients suffering from acute ST-elevation myocardial infarction (STEMI), it is controversial whether infarct location predicts worse clinical outcome independently of infarct size. We therefore aimed to investigate the prognostic relevance of infarct location in relation to infarct size in STEMI patients treated with contemporary primary percutaneous coronary intervention (PCI).
Myocardial infarction (MI) is the most common cause of cardiovascular morbidity and mortality worldwide. Despite the identification of many pathogenic genes associated with MI, the underlying molecular mechanisms remain poorly understood. MicroRNAs (miRNAs, miRs), which regulate target genes at the post-transcriptional level, play a significant role in the regulation of cardiovascular diseases such as MI. Pyroptosis is a caspase-1-dependent pro-inflammatory programmed cell death (PCD) mechanism.
Angina is the result of reduced blood flow to the heart and is an early warning sign that a patient might go on to have a heart attack or stroke.
Publication date: Available online 16 November 2019Source: Artificial Intelligence in MedicineAuthor(s): Anam Mustaqeem, Syed Muhammad Anwar, Muhammad MajidAbstractIn the last few years, hospitals have been collecting a large amount of health related digital data for patients. This includes clinical test reports, treatment updates and disease diagnosis. The information extracted from this data is used for clinical decisions and treatment recommendations. Among health recommender systems, collaborative filtering technique has gained a significant success. However, traditional collaborative filtering algorithms are facing ch...
A widely available anti-inflammatory agent used to treat pericarditis and gout may have value in secondary prevention after myocardial infarction, new trial results suggest.Medscape Medical News