Dynamics of immunocyte activation during intravenous immunoglobulin treatment in Kawasaki disease.

Conclusions: Our results suggest that insufficient control of monocyte suppression and T-cell activation, especially in terms of the CD8-related immune system, are associated with IVIG resistance. The restoration of T-cell suppression may be important for KD recovery. These findings provide insight into the mechanism of IVIG resistance.
PMID: 31272272 [PubMed - as supplied by publisher]

Source: Scandinavian Journal of Rheumatology - July 4, 2019 Category: Rheumatology Authors: Matsuguma C, Wakiguchi H, Suzuki Y, Okada S, Furuta T, Ohnishi Y, Azuma Y, Ohga S, Hasegawa S Tags: Scand J Rheumatol Source Type: research