Cocaine treatment before pregnancy differentially affects the anxiety and brain glucose metabolism of lactating rats if performed during adulthood or adolescence.

Cocaine treatment before pregnancy differentially affects the anxiety and brain glucose metabolism of lactating rats if performed during adulthood or adolescence. Behav Brain Res. 2019 Jul 02;:112070 Authors: Delgado H, Agrati D, Machado L, Reyes L, Savio E, Engler H, Ferreira A Abstract Cocaine exposure disrupts the maternal behavior of lactating rats, yet it is less known whether it alters the affective changes that accompany motherhood. As the long-term action of cocaine on anxiety varies according to the developmental stage of the individuals, this study aimed to compare the effect of a chronic treatment with cocaine to adult and adolescent non-pregnant females on their anxiety-like behavior and basal brain metabolic activity during lactation. Thus, adult and adolescent virgin rats were exposed to cocaine (0.0 or 15.0 mg/kg ip) during 10 days and were mated four days later. Anxiety behavior was evaluated on postpartum days 3-4 in the elevated plus maze test, and the basal brain glucose metabolism was determined on postpartum days 7-9 by means of [18F] fluorodeoxyglucose positron emission tomography. Cocaine treatment during adulthood increased the anxiety-like behavior of lactating females whereas its administration during adolescence decreased it. Also, the basal glucose metabolism of the medial prefrontal cortex differed between lactating females treated with cocaine during adulthood and adolescence. These differential effects of cocaine, ac...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research

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Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat CNN Facebook Source Type: news
In a world of social companion robots, chatbots, or artificial intelligence buddies, adults have the responsibility to teach kids well how to live a healthy life with the available technologies, how to balance between the online and the offline world, how to keep their mental stability in the face of innovations. As it’s an awfully difficult job, we collected examples where digital health technology could help and in which areas should analog methods prevail. The land where kindergarteners play with the texture of raspberry When was the last time you paid attention to the crunching sounds while eating a raw ca...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Health Sensors & Trackers apps children cognitive health digital health digital literacy eating fitness health apps health literacy healthy eating healthy lifestyle Innovation kids mental health physical Source Type: blogs
Conclusion: It seems to be feasible to combine different types of clinical characteristics with biomarkers in order to detect bipolarity of all depressive episodes. Neurotrophic factors of our interest presented its stable discriminant potentiality in unipolar and bipolar depression, deserving validation analysis in larger samples.IntroductionThe Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) separates the mood disorders into two sections: depressive and related disorders, and bipolar and related disorders. The new version of the diagnostic manual of bipolar disorders emphasizes more specific ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Yafeng Wang1,2,3, Yanan Wu2, Tao Li1,2,3, Xiaoyang Wang2,4 and Changlian Zhu2,3* 1Department of Neonatology (NICU), Children’s Hospital Affiliated Zhengzhou University, Zhengzhou, China 2Henan Key Laboratory of Child Brain Injury, Institute of Neuroscience and Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China 3Department of Clinical Neuroscience, Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden 4Department of Physiology, Sahlgrenska Academy, Institute of Neuroscience and Physiology, University of Gothenburg, ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: In vivo exposure to remifentanil exerts a beneficial effect against excitotoxicity on the developing mouse brain, which is associated with a reduction in the size of ibotenate-induced brain lesion as well as prevention of some behavioral deficits in young mice. The long-term effect of neonatal exposure to remifentanil should be investigated. Introduction The potential neurotoxicity of anesthetics in the perinatal period prompted the US Food and Drug Administration (FDA) to release a drug safety communication warning in 2016 that stated, “repeated or lengthy use of general anesthetics or sedation ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion The scientific basis of Olympic winter sports, as well as the studies of how athletes cope with the specific physiological and biomechanical requirements of their discipline, is of paramount importance and interest for exercise physiologists, sport scientists, and particularly coaches. These studies are necessary in order to improve the current understanding of Olympic winter sports performance. The continued evolution of Olympic winter sports is contributing to an enormous accumulation of knowledge, evidence, and relevant training technologies. In this context, the 18 papers that constitute this Research Topic...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion: This study found that HIV-infected pubertal children showed a delayed cortical maturation with atrophy. This abnormal pattern of cortical development may be the structural basis for cognitive impairment in HIV-infected children. Introduction Acquired immune deficiency syndrome (AIDS)-related encephalopathy is one of the most serious complications of AIDS and is more common in children than in adults (1). At present, there are nearly 2 million children living with human immunodeficiency virus (HIV) in the world, almost all newly infected children are infected through mother-to-child transmission (2). Effec...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: Journal of the Saudi Heart Association - Category: Cardiology Source Type: research
This study provides support for the notion that non-judgmental attention to the present moment facilitates the integration of regions in neural networks that are related to cognition, attention, and sensation. Introduction Originating in Buddhist traditions, mindfulness training has made its way into Western culture as a method to reduce stress, enhance emotional regulation, and reduce symptoms in a variety of mental health disorders (Teasdale et al., 1995; Farb et al., 2012; Cavanagh et al., 2013; Tabak et al., 2015). Indeed, mindfulness has been shown to reduce symptoms of depression (Chiesa et al., 2015), bipol...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
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