Interventions for treating neuropathic pain in people with sickle cell disease.

CONCLUSIONS: The included trial provided very low-quality evidence. Self-reported pain relief was greater in the pregabalin group compared to the placebo control group but only using the S-LANSS scale and we are very unsure whether there is a difference. While the pregabalin group tended to have improved quality of life over the duration of the trial, this was very low-quality evidence and we are uncertain whether there is a difference. Adverse effects and withdrawals were similar across the treatment and placebo control group in trial. There are both insufficient trials addressing this review question and insufficient outcomes addressed in the single included RCT. Therefore, there is still a significant gap in evidence on interventions for neuropathic pain in people with SCD. PMID: 31273755 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

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Authors: Ramos AR, Tarraf W, Wu B, Redline S, Cai J, Daviglus ML, Gallo L, Mossavar-Rahmani Y, Perreira KM, Zee P, Zeng D, Gonzalez HM Abstract INTRODUCTION: To determine if sleep-disordered breathing (SDB), daytime sleepiness, insomnia, and sleep duration predict seven-year neurocognitive decline in US Hispanics/Latinos (N = 5247). METHODS: The exposures were baseline SDB, daytime sleepiness, insomnia, and sleep duration. The outcomes were change in episodic learning and memory (B-SEVLT-Sum and SEVLT-Recall), language (word fluency [WF]), processing speed (Digit Symbol Substitution), and a cognitive ...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
This study intended to compare the benefits of 2 mind-body interventions-yoga and mindfulness-in a hospital setting. Design: The research team performed a retrospective analysis of outcome data obtained from a hospital's programs. Setting: The study took place at a mind-body center at a hospital in Athens, GA (USA). Participants: Participants were 46 individuals enrolled either in a yoga (n = 24) or a mindfulness (n = 22) intervention program at the hospital. Intervention: Participants self-selected a mind-body-intervention program offered at the hospital: yoga or mindfulness. They received guided training ...
Source: Advances in Mind Body Medicine - Category: Psychiatry Tags: Adv Mind Body Med Source Type: research
It's been my sense that this specialty is counter-cyclical in nature. If the economy tanks and more people are out of work, filing comp &disability claims, will this be good for the specialty?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
The objective of this study was to evaluate the impact of digital ulcers (DUs) in daily life of systemic sclerosis (SSc) Spanish patients. We developed a multicenter observational study to compare functional disability in SSc patients with active DUs vs. those without DUs. An additional correlation between perception of patients and physicians on disability due to DUs was performed. A total of 199 patients were enrolled, 70 (35%) with DUs. Patients with DUs were younger (48 vs. 58  years;p 
Source: Rheumatology International - Category: Rheumatology Source Type: research
This study aims to validate this observation. Blood levels of seven cytokines were measured in 120 patients with pSS from the United Kingdom Primary Sjögren’s Syndrome Registry and 30 age-matched healthy non-fatigued controls. Patient-reported scores for fatigue were classified acco rding to severity and compared to cytokine levels using analysis of variance. The differences between cytokines in cases and controls were evaluated using Wilcoxon test. A logistic regression model was used to determine the most important identifiers of fatigue. Five cytokines, interferon-γ-induced protein-10 (IP-10), tumour ne...
Source: Rheumatology International - Category: Rheumatology Source Type: research
Honestly, I typically wait atleast a 8months or 1 year before doing a SCS trial and usually after 1-2 ESIs didnt help. But I'm wondering if I'm too conservative.... Surgeons do their surgeries and usually tell patients, "it may take 6months to 1 year" to fuse. They tell their patients that we arent necessarily doing the surgery for pain, but to "stabilize" the spine. I was recently told that in theory if after 3months and there's no fusion or pseudoarthrosis, then one should consider... when after fusion/laminectomy do yo consider SCS therapy?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
The brain's pleasure centre begs for more food when you repeat this habit. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Sleep Weight Loss Source Type: blogs
Victoria Gray, 34, has been given fresh hope after taking part in a clinical trial where doctors from Nashville, Tennessee, gene-edited her cells using a method called CRISPR.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The unnamed woman from Vietnam woke up in sudden pain. At hospital, a doctor discovered a large cockroach stuck inside the canal which took a couple of minutes to remove.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Due to the collapse of the price of genetic testing and the FDA’s gradual ease of the regulatory environment, direct-to-consumer (DTC) genetic testing companies are booming. You can inquire your deoxyribonucleic acid about your ancestry, health risks, metabolism, and some start-ups even promise you to find true love or your kids’ talents. As the jungle of DTC companies is getting denser, more and more people ask me which genetic tests are worth the try. They love the possibility of getting access to their DNA but don’t know where to start. Here’s the DTC genetic testing kick-starter package! Naviga...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Genomics 23andme ancestry DNA DTC future genetic test Genetic testing genetics Genome genome sequencing Health 2.0 Source Type: blogs
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