Uncaria rhynchophylla and Its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions.

CONCLUSION: U. rhynchophylla and its major components possess multiple beneficial pharmacological actions on CNS. Futher studies on U. rhynchophylla and its major components are warranted to fully illustrate the underlying molecular mechanisms, pharmacokinetics, and toxicological profiles of these naturally occurring compounds and their potential for clinical application. PMID: 31272356 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research

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AbstractGambling is a popular activity among older adults. Despite this increase in popularity little research has examined gambling among this group. This is especially true for minority older adults, like Francophones in Ontario. The purpose of this study was to better understand gambling in a sample of older Francophones from North-Eastern Ontario, the first study to do so. A sample of 181 older (over 55  years) Francophones from Northeastern Ontario (M age = 68.7, SD 7.6) was recruited. This sample was compared to a sample of older adults with English as their native language that had been previously...
Source: Journal of Gambling Studies - Category: Addiction Source Type: research
CONCLUSIONS: These findings support the use of patient experiences and feedback to aide product development. In addition, post-9/11 veterans support the use of eScreening to assist health screening. However, evaluating the eScreening program in more diverse veteran groups and Veterans Affairs settings is needed to improve the generalizability of these findings to the larger veteran population. PMID: 32060553 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
DISCUSSION: This group, comprising the mothers of young children, is particularly interesting in view of the credit constraints experienced by younger households during the financial crisis in Ireland. Both sets of results are consistent with qualitative studies which have shown that mortgage difficulties can lead to depression, anxiety and poor mental health, and that high status groups experience shame and self-blame when they experience a financial loss. It remains to be seen if this will have a long-term effect on the mental health of either the mothers or their children. PMID: 32060231 [PubMed - in process]
Source: Journal of Mental Health Policy and Economics - Category: Psychiatry Tags: J Ment Health Policy Econ Source Type: research
Authors: Kolomeets NS, Uranova NA Abstract There is increasing evidence to support the notion that oligodendrocyte and myelin abnormalities may contribute to the functional dysconnectivity found in the major psychiatric disorders. The putamen, which is an important hub in the cortico-striato-thalamo-cortical loop, has been implicated in a broad spectrum of psychiatric illnesses and is a central target of their treatments. Previously we reported a reduction in the numerical density of oligodendrocytes and oligodendrocyte clusters in the prefrontal and parietal cortex in schizophrenia. Oligodendrocyte clusters contai...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Publication date: Available online 15 February 2020Source: Carbohydrate PolymersAuthor(s): Qiannian Wu, Mei Luo, Xiaodong Yao, Lan YuAbstractA new polysaccharide named COP-W1 was extracted from the root of Codonopsis tangshen Oliv using hot water extraction and ethanol precipitation. COP-W1, with a molecular weight of 2.34 × 104 Da, was purified using gel permeation chromatography. The monosaccharide composition of COP-W1 was mannose, rhamnose, glucose, and galactose, and its molar ratio was 20.32:1:1.27:36.13. Structural characterization of COP-W1 was confirmed by Fourier transform infrared spectrometr...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Global death toll reaches 1,775 with first case in Taiwan, as Canada prepares to airlift its citizens from Japan cruise ship. Follow live news and latest updates2.53amGMTThe economics research firm Capital Economics, has published some very interesting graphs which appear to show just how substantially activity in China has reduced as a result of the coronavirus outbreak.The first graph shows road congestion across 100 Chinese cities in the weeks before and after the lunar new year, comparing figures from the four years to 2020.2.29amGMTA fifth evacuation flight of Japanese citizens from Wuhan has landed in Tokyo.It landed...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak China Japan Hong Kong Australia news Asia Pacific Infectious diseases Science World news Source Type: news
Life after opioids: 'We have not served our patients well' More than 3 million Australians are living with chronic pain, and the medical system is struggling to help them as it turns away from its reliance on opioids www.theguardian.com “You may have a patient that has been on a stable dose of opioids for 10 years, and then you start de-prescribing. We are now exposing them to new risks for opioid overdose, for suicidality, for actual suicide, for withdrawal symptoms, for increased pain.” People living in chronic pain are a hi...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Diamond Princess evacuations begin as China announces death toll in country up to 1,665Hundreds of Americans have been flown out of Japan after leaving the quarantined Diamond Princess cruise ship on Sunday night, as a further 70 people onboard tested positive for Covid-19, bringing the total to 355.The removal of US citizens from the ship, moored at Yokohama, south of Tokyo, came as other countries said they would fly their citizens home just four days before the official quarantine set by Japanese health authorities was set to end.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Japan US news Medical research Science World news Canada Source Type: news
The malformations of cortical development (most FCD) were the most common pathological type for children cases in China with drug ‐resistant seizures. It was speculated further that the FCD patients with shorter duration of epilepsy before surgery seem to have a higher ratio of being seizure‐free after surgery. AbstractObjectivesThe drug ‐resistant seizures are characterized by frequent and severe onset of seizures in childhood. There is only little literature had extensively explored the types of pathological brain damage in Chinese children cases. The present study aims to investigate the histopathologic findings a...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
The objective of this study is to track and compare acute manic symptoms for sex differences during inpatient hospitalization.MethodsAll patients with bipolar mania admitted to a large university hospital between January and October 2017 were invited to participate in this longitudinal naturalistic follow ‐up study. Manic (YMRS), depressive (MADRS), and psychotic (PAS) symptoms were tracked daily from admission to discharge.ResultsThe total YMRS scores decreased significantly overtime (p 
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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