Ask D'Mine: What Type of Diabetes Do I Have?

Our weekly DiabetesMine advice column helps a woman understand whether she has type 1 or type 2 diabetes, or something in between.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs

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This study compared extracted structured EHR data to chart review from endocrinologists’ healthcare records at a large, academic ambulatory hospital in Ontario, Canada.MethodsConsecutive chart review for the first 10 patients with either type 1 or type 2 diabetes seen between January 1st, 2015 and March 1st, 2016, were sampled for each of the 10 endocrinologists within the diabetes program, and electronic data extraction was also completed for a core set of structured diabetes care elements. Fischer Exact test was used to determine differences in data availability between extracted EHR data to chart review.ResultsOut...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewIndividuals with type 1 and type 2 diabetes mellitus (T1DM, T2DM) have an increased risk of bone fracture compared to non-diabetic controls that is not explained by differences in BMD, BMI, or falls. Thus, bone tissue fracture resistance may be reduced in individuals with DM. The purpose of this review is to summarize work that analyzes the effects of T1DM and T2DM on bone tissue compositional and mechanical properties.Recent FindingsStudies of clinical T2DM specimens revealed increased mineralization and advanced glycation endproduct (AGE) concentrations and significant relationships between mecha...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Publication date: Available online 9 November 2019Source: Journal of Molecular BiologyAuthor(s): Eckhard Lammert, Peter ThornAbstractThe islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and are complex micro-organs embedded within the larger volume of the exocrine pancreas. Humans can have ∼3.2 million islets [1] which, to our current knowledge, function in a similar manner to sense circulating blood glucose levels and respond with the secretion of a mix of different hormones that act to maintain glucose concentrations around a specific set point [2]. At a cellular level the control...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
All people with type 1 diabetes (T1D) need insulin to survive, with the hope to cut or slow down the devastating long-term micro and macrovascular complications. About one fourth of people with type 2 diabetes (T2D) uses insulin, either as the only antyhyperglycemic drug, or in combination with other glucose-lowering medications [1,2]. Every day, about 6 million diabetic people in the U.S. inject insulin to control their hyperglycemia.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
When asked how his company came to develop the Actiste unified diabetes care device, Brighter CEO Henrik Norström recalled the difficulty experienced by the company founder’s wife when she was expecting her first child. As a Type 1 diabetic, she needed to monitor her blood sugar levels frequently. “The tools that were available then were independently good,” said Norström, “but as a group of tools they were not compatible because it was difficult just to remember what your last measurement of your blood sugar was, and if you d...
Source: MDDI - Category: Medical Devices Authors: Tags: Design Source Type: news
A Novel TNF-α Converting Enzyme (TACE) Selective Inhibitor JTP-96193 Prevents Insulin Resistance in KK-Ay Type 2 Diabetic Mice and Diabetic Peripheral Neuropathy in Type 1 Diabetic Mice. Biol Pharm Bull. 2019;42(11):1906-1912 Authors: Maekawa M, Tadaki H, Tomimoto D, Okuma C, Sano R, Ishii Y, Katsuda Y, Yoshiuchi H, Kakefuda R, Ohta T, Sasase T Abstract Tumor necrosis factor-α (TNF-α) converting enzyme/a disintegrin and metalloproteinase domain-containing protein 17 (TACE/ADAM17) is a key sheddase that releases TNF-α from its inactive precursor and is thought as a new drug targ...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
Vildagliptin blocks glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) inactivation of the meal induced increases in GLP-1 and GIP so that elevated GLP-1 and GIP levels are maintained over 24 h. The primary insulin secretion effect of vildagliptin is to improve the impaired sensitivity of the β-cells to glucose in subjects with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) and in patients with type 2 diabetes mellitus (T2DM); this effect was seen acutely and maintained over at least 2 years in patients with T2DM. Vildagliptin was also associated with improved &...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
AbstractRecent upswings in the use of continuous glucose monitoring (CGM) technologies have given people with diabetes and healthcare professionals unprecedented access to a range of new indicators of glucose control. Some of these metrics are useful research tools and others have been welcomed by patient groups for providing insights into the quality of glucose control not captured by conventional laboratory testing. Among the latter, time in range (TIR) is an intuitive metric that denotes the proportion of time that a person ’s glucose level is within a desired target range (usually 3.9–10.0 mmol/l [3.5&...
Source: Diabetologia - Category: Endocrinology Source Type: research
Molecules, Vol. 24, Pages 4020: Structure–Activity Relationship Study of Acyclic Terpenes in Blood Glucose Levels: Potential α-Glucosidase and Sodium Glucose Cotransporter (SGLT-1) Inhibitors Molecules doi: 10.3390/molecules24224020 Authors: Miguel Valdes Fernando Calzada Jessica Mendieta-Wejebe Twelve terpenoids were evaluated in the treatment of type 2 diabetes mellitus: seven monoterpenes (geranyl acetate (1), geranic acid (2), citral (3), geraniol (4), methyl geranate (5), nerol (6), and citronellic acid (7)), three sesquiterpenes (farnesal (8), farnesol (9), and farnesyl acetate (10)), one dite...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
New NHS figures revealed UK hospitals are being overrun by 1.7million type 2 diabetes admissions every year. Close to 10 per cent of people with type 2 diabetes could in fact have type 1.5.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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