Inverse association of Helicobacter pylori cagPAI genotypes with risk of cardia and non ‐cardia gastric adenocarcinoma

This study shows the reverse association ofH. pyloricagPAI genotypes (cagH+ andcagG+) with the risk of CGA in male patients aged  ≥ 55 in Iran. Moreover, presence of thevacAc2 genotype in combination withcagPAI genotypes showed strong inverse associations with the risk of CGA and non ‐CGA. These findings may reveal a coordinated relationship between thevacA c2 andcagPAI genotypes. AbstractIran is a high ‐risk country for cardia gastric adenocarcinoma (CGA) in Central Asia, with an incidence rate five times the average global rate, and shows a high infection rate forHelicobacter pylori (69%). The aim was to examine the associations of multipleH. pylori cagPAI genotypes (iecagH,cagL,cagG, andorf17) with the risk of CGA, non ‐CGA, and different histological types of GA in Iran. A large number ofH. pylori strains (N  = 336) were successfully cultured and genotyped. Histopathological evaluations were performed. The analysis showed an inverse association between thecagH+ genotype and the risk of CGA and intestinal ‐type gastric adenocarcinoma (IGA) (adjusted ORs; 0.312 and 0.283, respectively), where the controls were nontumors. Theorf17+ genotype decreased the risk of non ‐CGA and diffuse‐type gastric adenocarcinoma (DGA)(adjusted ORs; 0.310 and 0.356, respectively). When the controls were those with nonatrophic gastritis, thecagG+ genotype was negatively associated with the risk of CGA, non ‐CGA, IGA, and DGA (adjusted ORs; 0.324, 0.366, 0.306, and 0.303, res...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research