Molecules, Vol. 24, Pages 2483: Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics

In this study, for the first time, we demonstrated the efficacy of Compound A for the selective induction of apoptosis in melanoma cells and its interaction with tamoxifen, taxol, and cisplatin. We found that Compound A induced apoptosis selectively in human melanoma cells by increasing oxidative stress. The anti-cancer activity of Compound A was enhanced when combined with tamoxifen and the combination treatment did not result in significant toxicity to noncancerous cells. Additionally, Compound A did not interact negatively with the anti-cancer activity of taxol and cisplatin. These results indicate that Compound A could be developed as a selective and effective melanoma treatment either alone or in combination with other non-toxic agents like tamoxifen.

Source: Molecules - July 5, 2019 Category: Chemistry Authors: Krishan Parashar Siddhartha Sood Ali Mehaidli Colin Curran Caleb Vegh Christopher Nguyen Christopher Pignanelli Jianzhang Wu Guang Liang Yi Wang Siyaram Pandey Tags: Article Source Type: research