Leuco crystal violet-Pluronic F-127 3D radiochromic gel dosimeter.

Leuco crystal violet-Pluronic F-127 3D radiochromic gel dosimeter.
Phys Med Biol. 2019 Jul 04;:
Authors: Kouvati K, Jaszczak M, Papagiannis P, Kadlubowski S, Wach R, Maras P, Dudek M, Kozicki M
Abstract
This work reports results related to the manufacturing and optimisation of a leuco crystal violet (LCV)-Pluronic F-127 radiochromic gel dosimeter suitable for 3D radiotherapy dosimetry. A feature of this gel is that the natural gelatine polymer, which is most often used as a matrix in 3D dosimeters, is substituted with Pluronic F-127 synthetic copolymer (poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide). Pluronic F-127 ensures a higher transparency than gelatine, which may be beneficial for optical computed tomography readout, and improves the thermal properties in the temperature range above ~30 °C at which the gelatine physical gel converts to a solution. The optimal composition obtained comprises 2 mM LCV, 4 mM 4-(1,1,3,3-tetramethylbutyl)phenyl-polyethylene glycol (Triton X-100), 17 mM trichloroacetic acid (TCAA) and 25% Pluronic F-127. Its main dose-response features are 4‒150 Gy linear dose range (150 Gy was the maximal dose applied to gels in this work), 0.0070 Gy-1 cm-1 dose sensitivity (derived from absorbance (600 nm)=f(dose) for 6 MeV electrons, 0.88(3) Gy/s and 0.0156 Gy-1 cm-1 derived from optical density (Δμ)=f(dose) for 6 MV x-rays, 0.1010 Gy/s), low initial colour (initial absorbance = 0....

Source: Physics in Medicine and Biology - July 3, 2019 Category: Physics Authors: Kouvati K, Jaszczak M, Papagiannis P, Kadlubowski S, Wach R, Maras P, Dudek M, Kozicki M Tags: Phys Med Biol Source Type: research