Amiloride alleviates neurological deficits following transient global ischemia and engagement of central IL-6 and TNF- α signal.

CONCLUSION: Transient global ischemia induced by CA amplifies ASIC1a in the hippocampus likely via PIC signal. Amiloride administered into the central nerve system plays a neuroprotective role in the pathophysiological process of global ischemia. Thus, targeting ASICs (i.e., ASIC1a) has clinical implications for treatment and improvement of CA-evoked global cerebral ischemia often observed in clinics. PMID: 31272354 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31272354?dopt=Abstract

Source: Current Molecular Medicine - July 2, 2019 Category: Molecular Biology Authors: Pang L, Ji S, Xing J Tags: Curr Mol Med Source Type: research