The intervention mechanism of folic acid for benzo(a)pyrene toxic effects in vitro and in vivo

In conclusion, the mechanisms by which this effect is mediated were not entirely elucidated by our study, possibly because folic acid antagonizes the toxic effects of BaP by upregulating the levels of excision repair cross complementation group 1, xeroderma pigmentosum group A, and xeroderma pigmentosum group C gene expression to improve the rate of DNA repair, in turn accelerating the speed of repair for DNA damage caused by BaP. Meanwhile, folic acid could restrain BaP-induced cyclinD1 protein expression, which could help cells return to their normal cell cycle.
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Papers: Carcinogenesis Source Type: research