Hearing loss as a risk factor for cognitive impairment and loss of synapses in the hippocampus.

This study included four experimental groups based on hearing level and Aβ administration. Behavioral tests were conducted to evaluate cognitive function, and synaptic protein levels were measured in the hippocampus and prefrontal cortex. The group with hearing loss and Aβ administration showed significantly greater deficits on cognitive tests associated with the hippocampus than the other three groups (only Aβ administration, only hearing loss, and without hearing loss or Aβ administration). The hearing loss and Aβ administration group also had significantly lower levels of synaptic proteins in the hippocampus than the other groups. The present results suggest that hearing loss may act as a risk factor for cognitive impairment in Alzheimer's disease. Additionally, the present findings indicate hearing loss may cause hippocampal synapses to be more vulnerable to Aβ-induced damage. PMID: 31271817 [PubMed - as supplied by publisher]
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research