Intracerebroventricular administration of arginine vasotocin (AVT) induces anorexigenesis and anxiety-like behavior in goldfish
Publication date: Available online 4 July 2019Source: PeptidesAuthor(s): Koh Araishi, Keisuke Watanabe, Takumi Yamazaki, Tomoya Nakamachi, Kouhei MatsudaAbstractArginine vasotocin (AVT) is known as a neurohypophyseal hormone that regulates water- and mineral-balance in non-mammalian vertebrates. Recent studies revealed that AVT also exerts central effects on behavior. The goldfish has several merits for evaluation of behavioral changes. However, there is few information on the behavioral action of AVT in this species. Here we examined the effects of AVT on food intake and psychomotor activity. AVT was administered intracerebroventricularly at 1, 5 and 10 pmol g-1 body weight (BW). Intracerebroventricular (ICV) administration of AVT at 5 and 10 pmol g-1 BW significantly decreased food intake during 30 min after injection and recovery from anesthesia. The AVT-induced anorexigenic action was attenuated by treatment with the AVT receptor V1aR antagonist Manning compound (MC) at 50 pmol g-1 BW. As the goldfish tends to prefer the lower to the upper area of a tank, we used this preference behavior for assessing psychomotor activity during a 30-min observation period. ICV administration of AVT at 1, 5 and 10 pmol g-1 BW significantly prolonged the time spent in the lower area, but did not affect locomotor activity in the tank at any dose. The action of AVT was similar to that of the central-type benzodiazepine receptor inverse agonist FG-7142 at 10...
In Reply Thank you, Dr Pisano, for your insightful comments regarding our recent article. It is true that large analyses such as this should be examined critically and with an understanding of the limitations of large data sets. Regarding surgery duration, we did not adjust the analysis by surgery duration or use of regional blocks. While these could potentially be confounding factors related to pain in the immediate postoperative period and use of opioids, they would be unlikely to contribute to prolonged opioid use, which was the primary outcome analyzed in this study. Additionally, this level of detail for each procedur...
CONCLUSIONS: This retrospective study with propensity-matched cohorts showed that cannabinoid use was associated with higher pain scores and a poorer quality of sleep in the early postoperative period in patients undergoing major orthopedic surgery. PMID: 31425232 [PubMed - in process]
Co - use associated with anxiety and depression symptoms compared with opioid use alone
In this study, we investigated the temporal effects of electroacupuncture (EA) at acupoint ST36 on anxiety-like behaviors and the expression of c-Fos in the anterior cingulate cortex (ACC) in a rat model of PTSD. PTSD was induced by a single prolonged stress procedure comprising three stages: restraint for 2 h, forced swim for 20 min, and pentobarbital sodium anesthesia. EA at acupoint ST36 was performed from 7:00-9:00 once a day for 7 consecutive days. Open field test (OFT) and elevated plus maze (EPM) test were used to assess the success of the model and evaluate anxiety-like behaviors. Immunohistochemistry...
Listening to soothing music for a few minutes before getting a nerve-block might work as well as an anxiety drug to relax patients, a small study suggests.Reuters Health Information
ConclusionUsing an audiovisual method to inform patients about miniscrew placement increased anxiety levels but did not affect pain perception.
CONCLUSIONS: The CSPQ model can be effectively used to streamline the preoperative preparation of patients for cataract surgery while maintaining a high degree of patient satisfaction with the perioperative experience. PMID: 31358144 [PubMed - in process]
Health literacy is a well-established best practice that nurses can use to provide home care instructions post hospital stay. It is an excellent place to start, especially given the intensity of care, complexity of medications and importance of patient adherence. Nurses provide extensive information in a condensed period of time about how to take acre at home. With the anxiety of surgery, potential side effects of anesthesia and the time limitations of an outpatient setting, there is greater risk for patients being unprepared when they leave our care.
Peri-anesthesia patients can have prolonged wait times. This increases anxiety. This also leads to staff dissatisfaction, who feel helpless to resolve it. The Perioperative Clinical Practice Council (PCPC) addressed this using FOCUS-PDCA and a task force.
Conclusion and Recommendation: Our study showed higher magnitude of awareness with recall under general anesthesia. Lack of premedication was the only associated factor with awareness with recall under general anesthesia. Anesthetists should give emphasis to prevent the possibility of awareness under general anesthesia by providing premedication. Cohort studies should be done including the consequences of awareness with recall under general anesthesia. PMID: 31360165 [PubMed]