Vioxx and Diclofenac: Why Are Two Heart Risky Pain Drugs Viewed Differently?

More than a decade ago, Merck launched Vioxx (rofecoxib),  one of the first of a new class of pain relievers known as COX-2 inhibitors. These compounds, by virtue of their mode of action, were deemed to be as potent arthritis pain relievers as traditional non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen, but were believed to be safer than NSAIDs since they caused less gastrointestinal distress.  Vioxx was an immediate success with physicians and patients. New prescriptions for Vioxx soared.
Source: Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Publication date: Available online 5 April 2020Source: Journal of EthnopharmacologyAuthor(s): Felipe Marques Teixeira, Mariana Neubarth Coelho, Fernanda do Nascimento José-Chagas, David do Carmo Malvar, Alexandre Kanashiro, Fernando de Queiroz Cunha, Marcelo Dias Machado Vianna-Filho, Angelo da Cunha Pinto, Frederico Argollo Vanderlinde, Sônia Soares Costa
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
DUBLIN, April 6, 2020 -- (Healthcare Sales &Marketing Network) -- Perrigo Company plc (NYSE: PRGO; TASE) today announced that it was the first to receive approval from the U.S. Food and Drug Administration for its abbreviated new drug application (ANDA) ... Biopharmaceuticals, Generics, FDA Perrigo, Voltaren, Voltaren Gel, diclofenac
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
CONCLUSIONS: In EUA, physical and mood disorders are associated with new and old inflammatory serological, clinical and imaging biomarkers. HLA-DRB1*11-positivity may be protective against these disease-related features. PMID: 32242813 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Moreno-Fresneda P, Triguero-Martínez A, Olivas-Martínez I, Ortiz-Aljaro P, González-Escribano MF, Nuño-Nuño L, Ortiz AM, González-Álvaro I Abstract OBJECTIVES: To investigate the role of body mass index (BMI) in the phenotypic and genotypic characteristics of early arthritis patients. METHODS: We analysed the clinical and laboratory parameters from the baseline visit of patients (670 patients [78.51% women]) included in the PEARL study. The WHO definition for low weight, normal weight, overweight and obesity (BMI
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
CONCLUSIONS: PMR patients with long-term normal APR seem to be a milder subset of PMR in clinical presentation and prognosis. Additionally, our data also suggest there is a subgroup with normal APR who are caught early in the disease. Misdiagnosis does not appear to play a role. PMID: 32242804 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Girolimetto N, Macchioni P, Tinazzi I, Costa L, Peluso R, Tasso M, Bottiglieri P, Marchetta A, Possemato N, Salvarani C, McGonagle D, Scarpa R, Caso F Abstract OBJECTIVES: The aim of this study was to explore the link between specific sonographic findings and Leeds Dactylitis Index basic (LDI-b) score in psoriatic arthritis (PsA) patients with hand dactylitis. METHODS: Ninety-one hand dactylitis were evaluated in a multicentre study for the presence of pain, functional limitation and tenderness (2-point scale) and LDI-b score. Dactylitic fingers were investigated using high-frequency US in grey scale (...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Conclusions: People residing and actually ambulating in the mountain regions and exposed to the terrain have higher prevalence of Facet joint arthritis as compared to general population and this may be an independent risk factor for development of facet joint arthritis. However, a statistically significant relation between FJA and spinal pain exists only in cervical and dorsal spine.
Source: Journal of Craniovertebral Junction and Spine - Category: Orthopaedics Authors: Source Type: research
Though there have been no large-scale clinical trials of the drug's efficacy in treating coronavirus, chemists all over say they are facing a shortage of the medicine, not so long ago known mainly to those who had malaria or were prescribed it for arthritis pain. While the demand for hydrochloroqine has seen a rapid uptick, the safety and effectiveness of the drug in treating COVID-19 still remains a concern.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
This study aimed to assess clinical outcomes in patients who required syndesmosis fixation in the presence of arthroscopically proven instability, the hypothesis being that a delay to treatment would be associated with worse function.MethodA retrospective cohort study was performed of patients with dynamic instability requiring fixation between the years of 2010 –2016. The procedures were performed by two foot and ankle fellowship trained orthopaedic surgeons, over three hospital sites. Patients were classified into three groups based on the time since injury to surgery, acute syndesmotic injury (  6 mont...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - Category: Orthopaedics Source Type: research
ConclusionIn patients with symptomatic knee OA, the presence of knee CC did not affect the risk of arthroplasty or disease progression at 5 years.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
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