Protective effect of phosphatidylserine blockade in sepsis induced organ dysfunction

Phosphatidylserine is usually an intracellularly oriented cell membrane phospholipid. Externalized phosphatidylserine on activated cells is a signal for phagocytosis. In sepsis, persistent phosphatidylserine exposure is also a signal for activation of the coagulation and inflammatory cascades. As such, phosphatidylserine may be a key molecule in sepsis induced cellular and organ injury. We hypothesize that phosphatidylserine blockade provides a protective effect in sepsis induced organ dysfunction.

Source: Surgery - July 4, 2019 Category: Surgery Authors: Genna Beattie, Caitlin Cohan, Emily Miraflor, William Brigode, Gregory P. Victorino Source Type: research